摘要
可德胶是一种天然的直链型微生物发酵多糖,具有独特的凝胶特性,在食品及医药等领域有重要应用。可德胶不溶于水,这限制了其实际应用。因此对可德胶进行化学改性来扩大其应用范围,成为可德胶研究特别是其生物活性研究的重要方向之一。一些常用的多糖化学改性方法如磺酸化、羧甲基化等已被大量运用于可德胶改性上,这不仅极大改善了可德胶的水溶性,同时也赋予了可德胶更多的生物活性。本文综述了近年来国内外可德胶化学改性的研究进展,着重介绍了可德胶主链水解、磺酸化、羧甲基化、疏水改性等化学修饰的方法和发展动向。同时还介绍了"点击化学"这一最新的选择性化学修饰方法在可德胶化学改性中的应用。
Curdlan is a natural linear microbial polysaccharide possessing unique gelling properties and important applications in food and pharmaceutical fields. The chemical modification of has become one of the most important research aspects on curdlan. The water insolubility of curdlan significantly limits its practical application. Several common methods such as sulfated and carboxymethylated modification etc. have been applied on curdlan. These methods not only enhance the water solubility of curdlan, but also endow curdlan with more bioactivities. The present paper gives a summarization of recent progress in chemical modification of curdlan with emphasis on hydrolysis of the main chain, sulfation, carboxymethylation, and hydrophobic modification. The application of a new selective modification method - “Click Chemistry” on selective modification of curdlan is also introduced.
出处
《高分子通报》
CAS
CSCD
北大核心
2009年第5期20-29,共10页
Polymer Bulletin
基金
上海市重点学科建设资助项目(项目编号:B202)
关键词
可德胶
化学改性
生物活性
点击化学
自组装
Curdlan
Chemical modification
Bioactivity
Click chemistry
Self-assembly
