摘要
目的观察中西医药结合对2型糖尿病(DM)血糖及胰岛β细胞功能相关指标的影响。方法60例使用口服降糖西药而血糖控制不佳的2型DM患者分为2组,对照组30例患者继续原治疗方案,试验组30例患者在原治疗方案基础上再加用金芪降糖片,每次8～10片,3次/d。12周后观察血糖、胰岛素、C肽、糖化血红蛋白(HbA1C)及血脂的变化;同时以HOMA模型计算胰岛素分泌指数(Homa-β)、Homa胰岛素抵抗指数(Homa-IR)。结果12周后,试验组空腹血糖、餐后2h血糖、HbA1C和总胆固醇、三酰甘油显著下降,对照组无明显变化,两组差异有非常显著意义(P<0.01);空腹胰岛素、C肽无明显变化(P>0.05),餐后2h胰岛素、C肽升高(P<0.01),且两组差异有统计学意义(P<0.01)Homa-β上升了10±0.6,Homa-IR下降0.7±0.5(P<0.01)结论对于2型糖尿病患者辩证为气阴两虚火旺者,在应用西药降血糖时加用中成药金芪降糖片,还能改善胰岛B细胞功能。
Objective To investigate the effects of western medicine combining with traditional Chinese medicine on patients with T2DM and function of islet β cell. Methods 60 Type 2 diabetic patients with poor western medicine controlled Blood glucose were randomly divided into 2 groups, the control group and the trial group. 30 patients from the control group continue the original treatment. The trial group added Jinqijiangtangpian on the basis of the original treatment,8-10 tablets each time, threes times a day. Blood glucose , C peptide , HbA1C and blood fat were measured after 12 weeks and HOMA-β as well as Homa-IR were calculated by HOMA model. Results After 12 weeks , FBG ,2 h PBG , HbA1C and TC and TG were significantly lower than the control group （P〈0.01）. No difference were found in fasting insulin and C peptide （ P 〉 0.05）. 2 h postprandial insulin and C peptide rose （P 〈 0.01）. Homa-β rose by 10±0.6. Homa-IR declined by 0.7±0.5 （P 〈 0.01）. Conclusions To the patients with deficiency of both vital energy and yin, treatment of the Chinese formulated product Jinqijiangtangpian on the basis of western medicine can improve the islet β-cell function.
出处
《中国实用医药》
2009年第5期19-20,共2页
China Practical Medicine
关键词
血糖
胰岛功能
金芪降糖片
Blood glucose
Function of Islets
Jinqijiangtangpian
