摘要
目的观察左卡尼汀对促红细胞生成素治疗肾性贫血疗效的影响。方法将50例尿毒症血液透析患者随机分成治疗组和对照组,两组患者均于血液透析后皮下注射促红细胞生成素,剂量为每周100～150U/kg,待血细胞比容(Hct)上升至30%时后减量。同时治疗组每次血液透析后静脉注射左卡尼汀20～50mg/(kg.次),疗程12周。结果治疗组的血红蛋白(Hb)、血细胞比容水平显著高于对照组(P<0.01)。治疗组于治疗后第12周促红细胞生成素用量较治疗前明显减少,而对照组促红细胞生成素用量无明显改变。而两组血压升高发生率差异无统计学意义(P=0.182)。结论左卡尼汀能减少促红细胞生成素的用量及提高其疗效,纠正肾性贫血。
Objective To observe the curative effect of combination therapy with L-carnitine and eryth- ropoietin in hemodialysis patients with anemia. Methods 50 patients suffered from uremia were equally divided into the observation group and the control group in accordance with random double blind method. The normal therapy of two groups were the same, all patients were received subcutaneous injection with 100-150 U/kg erythropoietin once a week. The dosage of erythropoietin was reduced till the value of haematocrit increased by 30%, but the control group was injected via vein with L-carnitine 20-50 mg/kg every time after hemodialysis. The treatment course lasted 12 weeks. Results Compared with the observation group, the levels of hemoglobin and haematocrit were significantly increased in control group （P〈0.01）. After 12-week treatment, the dosage of erythropoietin in control group was reduced significantly while no remarkable change in observation group. No statistic significance was found in blood pressure＇s change between two groups （P=0.182）. Conclusion L-carnitine may reduce the dosage of erythropoietin and enhance the curative effect of erythropoietin, which can improve anemia.
出处
《中国实用医药》
2009年第5期15-16,共2页
China Practical Medicine
