摘要
核转录因子(nuclear factor-κB,NF-κB)是一个广泛存在于哺乳动物细胞中的转录因子,参与机体的免疫反应、细胞黏附、细胞分化、细胞增殖与凋亡及应激反应等。在奶牛感染乳房炎时,大部分涉及中性白细胞移行和激活的炎性蛋白质的编码基因在他们的启动子区都包含一个可结合NF-κB的κB位点,因此在一定程度上依赖NF-κB调控这些基因的表达。笔者详细的阐述NF-κB基因在奶牛乳房炎发病过程中的特点、作用和表达机制,为从分子水平认识和治疗奶牛乳房炎提供一定的文献支持。
Nuclear factor-κB （NF-κB） is widespread in mammal which is responsible for immune response, cell adhesion, differentiation, proliferation and apoptosis. Most of the genes encoding inflammatory proteins involved in neutrophil migration and activation have been shown to contain κB sites for the NF-κB within their promoter region and therefore partly depend on NF-κB for their expression,suggesting that this transcription factor might play a critical roles in the pathophysiology of mastitis. This paper summarized NF-κB characteristic, function and expression mechanism, for the purpose to give some fundamental messages to understand the mechanisms of dairy mastitis.
出处
《中国畜牧兽医》
CAS
北大核心
2009年第7期129-133,共5页
China Animal Husbandry & Veterinary Medicine
基金
国家973前期研究专项(2007LS700204)
国家自然科学基金课题(30760161)
