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2型糖尿病患者IGF-1水平及二甲双胍治疗对其的影响 被引量:2

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摘要 目的观察2型糖尿病(T2DM)患者血清胰岛素样生长因子-1(IGF-1)水平的改变,以及二甲双胍治疗半年后对其的影响。方法选择新发或病程少于5年、无并发症T2DM 43例(T2DM组),测定空腹及餐后2 h血糖、胰岛素I、GF-1水平。给予二甲双胍治疗6个月后,再次测定上述各指标。另外测定90例正常人群(对照组)空腹血清IGF-1水平作为对照。结果对照组IGF-1水平为(74.2±10.6)μg/L,T2DM组治疗前IGF-1水平为(44.8±5.6)μg/L,两者相比,有极显著性差异(P<0.01);二甲双胍治疗6个月后,T2DM组IGF-1水平为(57.8±7.6)μg/L,与治疗前相比,明显升高(P<0.05)。结论2型糖尿病患者IGF-1水平下降,二甲双胍治疗可改善2型糖尿病所导致的IGF-1水平变化。
出处 《实用临床医学(江西)》 CAS 2009年第6期46-47,共2页 Practical Clinical Medicine
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