摘要
目的观察乙型肝炎病毒前S1抗原(PreS1Ag)与HBeAg及HBV-DNA的关系,探讨PreS1Ag在乙肝病毒(HBV)检测中的实验室诊断价值及临床意义。方法收集乙型肝炎患者512例,检测HBV标志物、PreS1Ag、HBV-DNA。结果HBsAg、HBeAg、抗HBc阳性者142例,PreS1Ag、HBV-DNA阳性率分别为95.1%、95.8%;HBsAg、HBeAb、抗HBc阳性者316例,PreS1Ag、HBV-DNA阳性率分别为87.0%、88.9%;HBsAg、抗HBc阳性者54例,PreS1Ag、HBV-DNA阳性率分别为88.9%、92.6%,说明HBsAg阳性时,HBeAg阴性或HBeAb阳性/阴性的患者HBV-DNA阳性率仍然很高。HBV-DNA阳性时,PreS1Ag、HBeAg阳性率分别为98.1%、30.4%,两者检出率差异有显著性(P<0.01)。结论PreS1Ag较HBeAg更敏感地反映HBV复制状况。
Objective To observe the relation of presl antigen（PreS1Ag）with hepatitis B e-antigen （HBeAg） and HBV-DNA, and discuss the value of laboratory diagnostic tests and the clinical significance about PreSIAg. Methods A total of 512 serum samples were collected from HBV carriers. And the serums were examined for HBV Markers,PreS1Ag and HBV-DNA. Resuits One hundred and forty two HBsAg,HBeAg Ant-Hbc carriers were detected. The positive rates of PreS1Ag and HBV-DNA were 95.1% and 95.8% respectively. HBsAg, HBeAb and AntiHBc positive carriers were 316 patients. The positive rates Of PreS1Ag and HBC-DNA were 87.0% and 88. 9%. HBsAg and Anti-HBc positive carriers were 54. The positive rates of PreSIAg and HBV-DNA were 88.9% and 92.6%. The results suggeste that the virus still replicates in some carriers whose HBeAg shows negative while HBeAb positive or negative. While The HBV-DNA is positive. The coincidence rates of PreS1Ag,HBeAg reach 98.1% and 30.4%. It is more significance of different detection rates between HBeAg and PreS1Ag（P〈0.01）. Conclusion PreS1Ag reflects the HBV replication more sensitively than HBeAg.
出处
《实用临床医学（江西）》
CAS
2009年第6期17-18,共2页
Practical Clinical Medicine
