摘要
丙型肝炎是一种由丙型肝炎病毒引起的传染病。治疗丙型肝炎感染主要应用干扰素或干扰素加利巴韦林。干扰素治疗丙型肝炎可引起抑郁症,通常发生在干扰素治疗开始后1～8周,其发生率为17%～82%。引起抑郁症的因素涉及患者的遗传、治疗前的神经精神状态、丙型肝炎本身和干扰素的剂量、疗程、给药途径及制剂品种。干扰素诱发抑郁症的机制现认为:5-HT水平降低、下丘脑-垂体-肾上腺素皮质轴激活、炎性细胞因子活化以及细胞间粘附分子-1增多、氧化亚氮水平升高、二肽基肽酶水平降低。抑郁症的防治包括治疗前对患者状态的评估,以及出现抑郁症后对抗抑郁药的正确选用。
Hepatitis C is an infectious disease caused by hepatitis C virus. Treatment of hepatitis C viral infection is mainly to use interferon or interferon plus ribavirin. Depression may occur in the patients with hepatitis C following treatment with interferon. The time of depression onset is 1-8 weeks after starting interferon. The prevalence rate of interferon-induced depression is 17%-82%. The risk factors for depression occurring include patients＇heredity, neuropsychic condition before interferon treatment, hepatitis C itself, and the dosage, duration, administration route, and formulations of interferon. The mechanisms of interferon-induced depression are decreased 5-HT levels, hypothalamic-pituitary-adrenocortical （HPA） axis activation, proinflammatory cytokine activation, increased intercellular adhesion molecule-1, increased nitric oxide levels, and decreased dipeptidyl peptidase levels. Treatment and prevention of depression include assessment of patient condition before treatment and appropriate choice of anti-depression drugs after depression occurring.
出处
《药物不良反应杂志》
2009年第3期183-187,共5页
Adverse Drug Reactions Journal
关键词
丙型肝炎
干扰素
抑郁症
预防
治疗
hepatitis C
interferon
depression
prevention
treatment
