摘要
目的探讨阿托伐他汀钙对类风湿关节炎(RA)患者血清C-反应蛋白(CRP)、白细胞介素(IL-6)、肿瘤坏死因子(TNF)-α的影响。方法采集类风湿关节炎初治患者43例(RA组)和年龄、性别匹配的正常者40例(对照组),比较两组临床及实验室炎性指标,予RA组口服阿托伐他汀钙片20mg,1次/d,疗程12周,再比较RA组服药前后的临床及实验室炎性指标,分析阿托伐他汀钙片对CRP、IL-6及TNF-α的影响。结果CRP、IL-6及TNF-α,RA组较对照组均明显升高(P<0.05),RA组服药后较服药前三者均明显降低(P<0.05)。结论RA存在全身性炎症反应,阿托伐他汀钙可减轻RA患者的炎症反应,控制这种炎症反应所促使的动脉粥样硬化。
Objective To investigate the effect of atorvastatin on serum C-reactive protein（CRP）、interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α）in patients with rheumatoid arthritis（RA）. Methods 43 patients with RA were enrolled as RA group（atorvastatin,20 mg,qd for 12 weeks）,35 control subjects were chosen after match-pairing by age and sex. Measurement of serum CRP、IL-6 and THF-αwere repeated after treatment. Results The serum CRP、IL-6 and TNF-αlevel of RA group were all higher significantly than control group（P〈0.05）; in RA group,CRP、IL-6 and TNF-αlevel were all decreased after treatment（P〈0.05）.Conclusion RA was associated with systemic inflammation,atorvastatin could abate the inflammatory reaction and protect the RA patients from artherosclerosis.
出处
《中国实用医药》
2009年第6期63-65,共3页
China Practical Medicine
