摘要
目的探讨重组人干扰素α-2b凝胶预防宫颈电热圈环形切除术（IJEEP）术中、术后出血的有效性。方法152例行LEEP宫颈疾病患者随机分为A组（46例）：术前重组人干扰素α-2b凝胶阴道给药；B组（56例）：术中垂体后叶素局部给药；C组（50例）：未用药。结果A组术中、术后出血量分别为（2．57±1．19）、（2．24±1．75）ml，B组分别为（3．00±1．49）、（45．86±26．14）ml，C组分别为（45．62±39．57）、（56．90±41．90）ml，A组与B组术中出血量比较差异无统计学意义（P〉0．05）。A、B组术中出血量与C组比较差异有统计学意义（P〈0．01）；B组与C组术后出血量比较差异无统计学意义（P〉0．05），B、C组术后出血量与A组比较差异有统计学意义（P〈0．01）。结论使用LEEP治疗宫颈疾病术前建议使用重组人干扰素α-2b凝胶，以减少术中、术后出血。
Objective To evaluate the efficacy of recombinant human interferon α-2b gel on flooding prevention in loop electrosurgical excision procedure （LEEP） during and after the operation. Method The 152 patients with cervical disease were randomly divided into three groups： group A （recombinant human interferon α-2b gel treatment group）, group B（hypophysin treatment group）and group C（control group）. Results The amount of intraoperative bleeding and the amount of post-operative bleeding of the group A was （2.57 ± 1.19） ml and （2.24 ± 1.75） ml, the group B was （3.00± 1.49） ml and （45.86 ± 26.14） ml, the group C was （45.62 ±39.57） ml and （56.90± 41.90） ml, respectively. There was no difference between group A and group B in the amount of intraoperative bleeding （P 〉 0.05 ）, but significantly less than group C （P 〈 0.01 ）. There was no difference between group B and group C in the amount of post-operative bleeding （P 〉 0.05）, but significantly much more than group A （P 〈 0.01 ）. Conclusion Recombinant human interferon α-2b gel is effective on reducing intraoperative and post-operative bleeding in LEEP.
出处
《中国医师进修杂志》
2009年第7期19-22,共4页
Chinese Journal of Postgraduates of Medicine
关键词
干扰素Α-2B
宫颈疾病
妇科外科手术
手术后出血
Interferon alfa-2b
Uterine cervical diseases
Gynecologic surgical procedures
Postoperative hemorrhage
