摘要
以价廉易得的苯丁醇和邻羟基苯甲醛为起始原料,通过多步反应制备得到平喘新药沙美特罗,该方法路线较短,后处理简便易行,反应条件温和,收率较高,有利于工业化生产,沙美特罗的结构经1H NMR予以确证,沙美特罗羟基萘甲酸盐的熔点与文献报道一致.
Starting from inexpensive phenylbutanol and o-hydroxybenzaldehyde, salmeterol was synthesized via a few steps, which is a unique long-acting selective β2-adrenoreceptor agonist. This synthetic route has following characteristics, fewer reaction steps, easy and convenient aftertreatment, mild reaction condition without harzardous chloromethylation and bromination. The structure of salmeterol was confirmed hy ^1H NMR, the melting point of salmeterol xinafoate and the IR spectrum accord with the literature.
出处
《西南师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2009年第4期85-88,共4页
Journal of Southwest China Normal University(Natural Science Edition)
基金
四川师范大学博士点启动基金资助项目(037166)
关键词
沙美特罗
合成
邻羟基苯甲醛
salmeterol
synthesis
o-hydroxybenzaldehyde
