摘要
目的:观察川牛膝多糖对S180荷瘤小鼠、H22肝癌小鼠的肿瘤抑制作用以及川牛膝多糖对环磷酰胺(Cy)所致小鼠(正常及荷瘤小鼠)外周白细胞减少的影响。方法:以动物移植性肿瘤荷瘤S180、肝癌为模型,环磷酰胺(Cy)为阳性对照,生理盐水为阴性对照,观察川牛膝多糖抗肿瘤作用;通过白细胞计数观察川牛膝多糖对环磷酰胺(Cy)所致外周白细胞减少的回升作用。结果:川牛膝多糖对S180荷瘤小鼠的抑瘤率为10.00-48.08%;对肝癌H22实体瘤的小鼠肝癌H22的抑制率为21.99-42.21%;对环磷酰胺(Cy)所致正常或荷瘤小鼠外周血白细胞减少有极显著的回升作用。结论:川牛膝多糖不仅有较强的抗肿瘤作用,还能对环磷酰胺(Cy)所致小鼠(正常及荷瘤小鼠)外周白细胞减少有明显的回升作用。
Objective： observing on Achyranthes Bidentata Polysacharides （ABP） inhibit tumor of sacoma180 （S180） mice and Hepatocarcinoma22 （H22） mice,and affect on mice （normal or （S180） that received Cyclopsosphamide （Cy） which leaded extra-leucocytopenia Methods By means of removed S180 and Hepatocarcinoma mice as a model,Cyclopsosphamide as positive contrast ,compared with normal saline group,obsersve ABP action on anti-tumor.Observing on ABP resuscitate action . Results The anti-tumor rate to S180 tumor model mice of ABP is10.00-48.08%; Hepatocarcinoma22 model mice is 21.99-42.21%.ABP can transparently resuscitate extra-leucocytopenia of mice （normal or S180） that lead by Cylophamide.Conclusion ABP can not only has fairly strong anti-tumor action,but also can transparently resuscitate extra-leucocytopenia of mice （normal or S180） that leaded by Cyclophosphamide.
出处
《中国民族民间医药》
2009年第13期46-47,115,共3页
Chinese Journal of Ethnomedicine and Ethnopharmacy
关键词
牛膝多糖(ABP)
荷瘤S180
肝癌H22
抗种瘤作用
白细胞(Wbc)
回升作用
Achyranthes Bidentata polysaccharides （ABP）
sarcoma 180 （S180）
Hepatocarcinoma22 （H22）
Anti-tumor activity
Leucocyte （WBC）
Resuscitate activity
