摘要
目的：通过对妊娠中期染色体病高危胎儿进行染色体核型分析，对染色体病所致的畸形儿进行产前诊断，探讨胎儿染色体病的发生情况。方法：对2003年9月～2008年9月中国医科大学附属盛京医院2068例染色体病高危孕妇进行羊膜腔穿刺或胎儿脐静脉穿刺，采取细胞培养，制备中期染色体，分析胎儿核型，进行产前诊断。结果：在2068例胎儿染色体核型中，发现染色体异常68例，异常率为3．29％，其中数目异常41例，结构异常27例。结论：妊娠中期对染色体病高危胎儿进行羊水或脐血染色体核型分析是产前诊断的重要方法，孕母血清筛查、B超检查并结合孕妇高龄等是发现染色体病胎儿的重要措施。
Objective： To explore the incidence of chromosomal diseases in fetuses by analyzing chromosome karyotypes on the high risk population of chromosomal diseases. Methods： 2 068 pregnant women with high risk of chromosomal diseases in their fetuses underwent amniocentesis or percutaneous umbilical blood sampling from September 2003 to September 2008, then karyotypes of their fetuses were analysed. Results： 68 fetuses were found chromosome abnormalities, the rate was 3.29%, including 44 fetuses of numerical abnormality and 19 fetuses of structural abnormality. Conclusion： Chromosomal karyotypes analysis on high risk population in the mid trimester of pregnancy is an important prenatal diagnosis method. Serum screening, B ultrasound screening and advanced maternal age are important measures tO find ietus with chromosomal diseases.
出处
《中国妇幼保健》
CAS
北大核心
2009年第22期3096-3098,共3页
Maternal and Child Health Care of China
关键词
染色体病
核型
胎儿
产前诊断
Chromosomal diseases
Karyotypes
Fetus
Prenatal diagnosis
