摘要
目的探讨脑源性神经营养因子（BDNF）基因多态性与双相障碍的关联性。方法以228例双相障碍患者和362名正常对照者为研究对象，通过TaqMan探针单核甘酸多态性（SNP）基因分型技术对BDNF基因及基因上游10kh区域的标签SNPrs6265和rs11030101进行基因分型，比较各组间基因型、等位基因及联合基因型分布频率。结果双相障碍患者与正常对照的SNPrs6265和rs11030101基因型、等位基因及联合基因型分布频率比较差异无统计学意义；男女分层、不同临床类型以及不同发病年龄的双相障碍患者与正常对照的基因型、联合基因型之间比较差异均无统计学意义。结论研究未发现在中国汉族人群中脑源性神经营养因子基因多态性SNPrs6265和rs11030101与双相障碍有关。
Objective To investigate the association between brain-derived neurotrophic factor （BDNF） gene polymorphism and bipolar disorder. Methods Single nucleotide polymorphisms rs6265 and rs11030101 in BDNF gene were detected and compared between 228 patients with bipolar disorder and 361 healthy controls. Results The genotypes, alleles and eombinative genotype of BDNF gene single nueleotide polymorphism rs6265 and rs11030101 did not show significant differences between two groups. There were also no significant differences in genotypes and combinative genotypes between diagnostic subtypes, genders and on-set age of bipolar disorder and controls. Conclusion This study did not found that BDNF gene single nucleotide polymorphism rs6265 and rs11030101 are associated with bipolar disorders.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2009年第27期1897-1901,共5页
National Medical Journal of China
基金
美国stanley医学研究院基金（021-008）
关键词
脑源性神经营养因子
双相障碍
单核甘酸多态性
Brain-derived neurotrophic factor
Bipolar disorder
Single nucleotide polymorphism
