摘要
目的评估布地奈德/福莫特罗干粉吸入剂和喘可治注射液联合治疗儿童支气管哮喘(轻度持续—中度持续)的临床疗效、依从性和安全性。方法采用随机、开放、平行对照研究方法,将64例患儿分为A组(布地奈德/福莫特罗干粉吸入剂组)37例和B组(布地奈德/福莫特罗干粉吸入剂+喘可治联合治疗组)27例,观察临床症状评分、视觉近似评价量尺(VAS量尺)、儿童哮喘控制测试(ACTCH)、最大呼气峰流速(PEF占预计值%)、肺功能(FEV1占预计值%)和不良事件发生情况。结果A、B两组药物治疗都可改善患儿的临床症状,但B组改善更明显(P<0.05);PEF占预计值%和FEV1占预计值%方面,两组都有改善,B组在治疗后4周改善PEF占预计值%快于A组(P<0.05),在治疗后4周、8周、12周改善FEV1占预计值%也优于A组(P<0.05),两组无明显不良事件发生。结论布地奈德/福莫特罗干粉吸入治疗和布地奈德/福莫特罗干粉吸入剂+喘可治联合治疗儿童支气管哮喘(轻度持续—中度持续)都具有良好的疗效和安全性,依从性好,但布地奈德/福莫特罗干粉吸入剂+喘可治联合治疗改善病情更快,疗效更好。
Objective To evaluate the clinical efficacy, compliance and safety of the combination therapy of budesonide/foradil powder for inhalation and Chuankezhi in the treatment of bronchial asthma in children （mild to moderate persistent）. Methods In this open, randomized, parallel control study, 64 patients were divided into group A （budesonide/foradil powder for inhalation group） of 37 patients and group B （combination of budesonide/foradil powder for inhalation and Chuankezhi group） of 27 patients. Clinical symptom scale, visual analog scale （VAS）, children asthma control test （ACTCH） , peak expiratory flow （PEF predictive value % ）, lung function （FEV1 predictive value % ） and adverse-events were observed. Results The clinical symptoms were improved in both groups, but was more significant （P 〈 0.05） in group B. PEF predictive value % and FEV1 predictive value % was also improved in both groups. The improvement of PEF predictive value % in group B was faster than in group A after treatment for 4 weeks （P 〈 0.05）. After treatment for 4 weeks, 8 weeks, and 12 weeks, the improvement of FEV1 predictive value % in group B were better than in group A （P 〈 0.05）. No adverse-events were observed in both groups. Conclusions The budesonide/foradil powder for inhalation group （A） and the combination of budesonide/foradil powder for inhalation and Chuankezhi group （B） both have good clinical efficacy, compliance and safety, but the latter provides more rapid improvement and better efficacy than the former.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2009年第7期682-685,共4页
Journal of Clinical Pediatrics
