摘要
目的:探讨趋化因子受体CXCR4在胃癌中的表达及其临床意义。方法:采用免疫组织化学方法检测60例经病理检查确诊胃癌患者胃癌组织及癌旁组织CXCR4表达情况,探讨其与临床病理特征的关系。结果:胃癌组织及癌旁组织中均可检测到CXCR4的表达,胃癌组织的表达水平明显高于癌旁组织(P<0.05)。CXCR4在胃癌原发灶中的表达与肿瘤分期、分化程度及淋巴结转移相关(P<0.05),与患者年龄、性别、肿瘤部位、大小无相关性(P>0.05)。结论:胃癌组织高表达CXCR4趋化因子受体,其表达与肿瘤的分期、分化程度及淋巴结转移有关,有望成为判断胃癌预后的指标。
Objective To investigate the expression and clinical significance of CXCR4 in gastric cancer. Methods Immunohistochemical technique was used to detect the expression of CXCR4 in gastric cancer and adjacent tissues of 60 patients. Results CXCR4 could be detected in gastric cancer and adjacent tissues. The expression level of CXCR4 was up-regulated in gastric cancer tissue as compared with adjacent tissues. The expression of CXCR4 in gastric cancer was significantly related to tumor stage, pathological differentiation and lymph node metastasis（P〈0.05）, but not related to sex, age, location of tumor or tumor size （P〉0. 05）. Conclusion CXCR4 is expressed in gastric cancer. The expression level of CXCR4 is related to tumor stage, tumor differentiation and lymph node metastasis. CXCR4 may serve as a potential marker to evaluate the prognosis of gastric cancer.
出处
《中华实用诊断与治疗杂志》
2009年第7期665-666,共2页
Journal of Chinese Practical Diagnosis and Therapy
