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MicroRNA在神经疾病研究中的作用 被引量：3

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摘要 MicroRNA(miRNA)是一种内源性非编码RNA,它在mRNA后转录水平调节靶基因转录与表达。近年来国内外研究表明,miRNA在阿尔茨海默病、帕金森病、亨廷顿病等神经变性疾病中起着重要的作用。miRNA在Rett综合征中的作用表明特殊miRNA可能参与癫痫的发生,具体机制有待深入研究。
作者 张姝 宋毅军
机构地区 天津医科大学总医院 天津医科大学总医院神经内科/天津市神经病学研究所
出处 《国际神经病学神经外科学杂志》 2009年第3期279-282,共4页 Journal of International Neurology and Neurosurgery
关键词 MICRORNA 基因 神经系统变性疾病 癫痫
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献20

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同被引文献67

  • 1宋毅军,田心.经颅磁刺激对颞叶癫痫大鼠海马代谢功能的影响[J].中华物理医学与康复杂志,2005,27(2):75-78. 被引量：5
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  • 3Fukuoka Y, Tashiro M, Uchiyama T. Systemes analysis of interactions between microRNAs and genes in hepatocellular carcinoma[J]. Conf Proc IEEE Eng Med Biol Soc, 2013,2 013 6OO-603.
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  • 5Lee RC, Feinbaum RL, Ambros V. The C. elegans hetero- chronic gene lin-4 encodes small RNAs with antisense com- plementarity to lin- 14[J]. Cell, 1993,75(5): 843- 854.
  • 6Tang F,Kaneda M, O'Carroll D, et al. Maternal microRNAs are essential for mouse zygotic development[J]. Genes Dev, 2007,21 (6) : 644- 648.
  • 7Tay YM,Tam WL, Ang YS, et al. MicroRNA-134 modu- lates the differentiation of mouse embryonic stem cells, where it causes post transcriptional attenuation of Nanog and LRHI [J]. Stem Cells,2008,26(1) : 17-29.
  • 8Sathyan P, Golden HB, Miranda RC. Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium[J]. J Neurosci,2007,27(32) :8 546-8 557.
  • 9Chan SH, Wu CW, Li AF, et al. MiR-21 microRNA ex- pression in human gastric carcinomas and its clinical association[J]. Antieancer Res,2008,28(2A):907-911.
  • 10Sengupta S,denBoon J A,et al. MicroRNA 29c is down-reg- lalated in nasopharyngeal carcinomas, up-regplating mRNAs encoding extracellI, tlar matrix proteins[J]. Proc Natl Aead Sci U S A,2008,105(15) :5 874-5 878.

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国际神经病学神经外科学杂志
2009年 第3期

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