摘要
实验选用健康杂种犬２１只，分为种植组（ｎ＝１３），即用自体静脉碎片种植涤纶人工血管（Ｄａｃｒｏｎ）间置于下腔静脉（ＩＶＣ）；对照组（ｎ＝８）所用Ｄａｃｒｏｎ仅全血预凝。采静脉血行血浆及血小板环磷酸腺苷（ｃＡＭＰ）和环磷酸鸟苷（ｃＧＭＰ）放免测定，并定期取移植物行形态观察。结果：种植组移植物通畅率为６１．５％，对照组为２５．０％；术后２周种植组Ｄａｃｒｏｎ腔面形成内皮层，对照组为血栓；种植组血浆与血小板ｃＡＭＰ高于对照组，ｃＧＭＰ低于对照组。本实验结果提示：自体静脉碎片种植可促使植入犬ＩＶＣ的Ｄａｃｒｏｎ内皮化、血浆与血小板ｃＡＭＰ含量增加及ｃＧＭＰ含量减少。
The Dacron grafts seeded with autologous venous fragments were implanted into IVC of 13 canines as seeded group and the control grafts (8 cases), which were only preclotted with fresh blood. The amounts of cAMP and cGMP in serum and within platelet were measured. All of the specimens explanted at exsaguination were observed morphologically. The results shown that the total patency rate were 61.5% in seeded group, but 25.0% in control one and new endothelial lining formed at two weeks after implantation of the seeded grafts. The amounts of cAMP in serum and within platelet were higher in seeded group, but the amounts of cGMP were lower in serum and within platelet. These were in accordance with the results that the endothelialization of the grafts were complete in seeded group but not complete in control one. The results indicate that seeding Dacron with autologous venous fragment makes new endothelium formed at two weeks after implantation, increases the amounts of cAMP in serum and within platelet, but reduces the amounts of cGMP and thus improves graft patency rate.
出处
《中国普外基础与临床杂志》
CAS
1998年第4期211-213,共3页
Chinese Journal of Bases and Clinics In General Surgery
关键词
下腔静脉重建
涤纶人工血管
内皮化
Inferior vena cava reconstruction
Dacron
Endothelialization
cAMP
cGMP
