摘要
为探讨铝对免疫系统的影响，给小鼠每天腹腔注射氯化铝（ＡｌＣｌ３）溶液〔１０，２５，４０ｍｇ／（ｋｇｄ）〕，连续注射２，４，６周。结果表明：染铝４周后脾重及２５ｍｇ／ｋｇ、４０ｍｇ／ｋｇ组的ＰＦＣ值、ＣＤ３＋、ＣＤ４＋、ＣＤ４＋／ＣＤ８＋、ＡＮＡＥ阳性率均显著增加，６周后各剂量组的脾重、ＰＦＣ值及２５ｍｇ／ｋｇ组的ＣＤ４＋，ＣＤ４＋／ＣＤ８＋、ＡＮＡＥ和４０ｍｇ／ｋｇ组的ＣＤ３＋、ＣＤ４＋、ＣＤ８＋、ＡＮＡＥ均显著增加，并且随染铝时间延长，４０ｍｇ／ｋｇ组的ＰＦＣ值、ＣＤ３＋、ＣＤ４＋、ＣＤ４＋／ＣＤ８＋及ＡＮＡＥ呈先升高后下降趋势，而ＣＤ８＋呈上升趋势，提示铝对小鼠免疫系统具有影响作用。
Aluminum chloride solution〔10,25 and 40 mg/(kg·d)〕was injected into mice intraperitoneally for two,four and six weeks,respectively,to explore the effects of aluminum on immune system.Results showed that the weight of spleen,PFC,proportions of CD3+ and CD4+,the ratio of CD4+/CD8+,and αnaphthyl acetate enzyme(ANAE)were all significantly increased in the groups four weeks after exposure to 25 and 40 mg/kg of aluminum.Both of the weight of spleen and PFC significantly increased in all groups,and proportions of CD4+,the ratio of CD4+/CD8+,and ANAE increased in the group with 25 mg/kg of aluminum and proportions of CD+3 and CD+4,the ratio of CD+4/CD+8,and ANAE were all significantly increased in the groups with 40 mg/kg of aluminum six weeks after exposure.There was a tendency that PFC in the group with 40 mg/kg of aluminum and proportions of CD+3 and CD+4,the ratio of CD+4/CD+8,and ANAE were all increased at first and then lowered with the length of exposure.But,CD8+ showed a rising trend.It suggests that effects of aluminum on immune system in mice were dual direction in nature.
出处
《中国工业医学杂志》
CAS
1998年第3期137-139,共3页
Chinese Journal of Industrial Medicine
关键词
铝
抗体生成细胞
T淋巴细胞亚群
ANAE
luminum,P forming cells(PFC),Subgroup of Tlymphocyte,αnaphthyl acetate enzyme(ANAE)
