摘要
目的探讨血清HBsAg定量检测的临床应用价值。方法采用化学发光微粒子免疫分析技术定量测定7612例非肝炎相关病区住院患者的血清HBsAg浓度，分析血清HBsAg水平的人群分布特征及与其他HBV血清学标志物（抗-HBs、HBeAg）和HBV DNA之间的关系。结果870例患者检出血清HBsAg阳性，阳性率为11．4％（870／7612），浓度范围为0．08～125000．00U／mL，中位数值为932．28U／mL。比较男、女患者血清HBsAg浓度差异无统计学意义（Z=-0．366，P〉0．05）。血清HBsAg浓度与患者年龄呈负相关（r=-0．370，P〈0．01），与血清HBeAg和HBV DNA水平呈正相关（r分别为0．654和0．765，P值均〈0．01）。结论血清HBsAg定量检测有利于精确反映乙型肝炎患者HBV复制和清除情况。
Objective To investigate the clinical significance of quantitative detection of serum HBsAg. Methods Serum concentrations of HBsAg were detected by ehemiluminescent mieropartiele immunoassay in 7612 hospitalized non-hepatitis patients. The distribution of HBsAg positive patients and the relationship of HBsAg concentration with serum anti-HBs, HBeAg and HBV DNA were analyzed. Results The HBsAg positive rate was 11.4% （870/7612 ） in this series. The serum HBsAg ranged from 0.08 U/mL to 125 000 U/mL with a median of 932. 28 U/mL. No significant difference of HBsAg concentrations between male and female patients was observed （Z = - 0. 366,P 〉 0.05 ）. There were negative correlation of HBsAg concentration with the age of patients （r = - 0. 370, P 〈 0.01 ）, and positive correlations of HBsAg with HBeAg （ r = 0. 654, P 〈 0.01 ） and HBV DNA levels （ r = 0. 765, P 〈 0.01 ）. Couclusion The quantitative determination of serum HBsAg may be useful in estimating the hepatitis B viral replication and clearance.
出处
《中华临床感染病杂志》
CAS
2009年第3期143-146,共4页
Chinese Journal of Clinical Infectious Diseases
基金
浙江省科技厅计划资助项目（2007C23G1360002）
关键词
肝炎表面抗原
乙型
化学发光微粒子免疫分析
定量检测
Hepatitis B surface antigens
Chemiluminescent mieroparticle immunoassay
Quantitative detection
