摘要
目的:通过检测实验性肝硬化各阶段3种内源性阿片肽(EOP)血浆浓度变化,探讨其与肝硬化高动力循环状态及腹水形成的关系.方法:应用放射免疫法测定了四氯化碳(CCl_4)诱发大鼠肝硬化过程中血浆3种EOP的含量变化.结果显示:肝硬化腹水组及肝硬化无腹水组血浆亮啡肽(L-ENK)、强啡肽(Dyn Al-13)的含量均显著高于正常对照组(P<0.01,P<0.05),而且升高的水平与肝功能损害的程度呈显著正相关,但血浆β内啡肽(β-EP)的含量在3组中无显著差异(P>0.05).提示肝脏灭活功能受损导致大鼠血浆小分子阿片肽含量升高,后者又是引起实验性肝硬化高动力循环状态及腹水形成的原因之一.
The changes of three kinds of endogenous opioid peptides contents in plasma were investigated in 20 healthy control rats and 37 liver cirrhosis rats (17 with ascites and 20 without ascites) induced by carbon tetrachloride by radio-immunoassay. The result showed that both L-ENK and Dyn Al-13 increased markedly in two groups of cirrhosis rats compared with those of healthy controls ( P < 0 . 01 and P < 0. 05 ). The increases of L-ENK and DynAl-13 in plasma were proportional to the various degrees of liver damage. But there was no significant difference of β-EP among three groups (P >0. 05). These results suggested that the rise of small opioid peptides in plasma mainly result from damagod liver function, which attribute to hyperdynamic circulation state and ascites formation in cirrhosis rats.
出处
《临床消化病杂志》
1998年第2期60-63,共4页
Chinese Journal of Clinical Gastroenterology
