摘要
目的：为探讨缺氧和营养不良对大鼠膈肌超微结构的影响及红景天保护的作用；方法：Ｗｉｓｔａｒ大鼠３２只，随机分为四组，Ａ组为对照组，Ｂ组为缺氧组（氧浓度１１±０．５％），每日缺氧８小时，Ｃ组为缺氧加红景天组，缺氧同Ｂ组，缺氧前灌服红景天１．０ｇ／ｋｇ·ｄ，Ｄ组为营养不良组，每日给予正常食量的１／２。实验期限共五周；结果：Ｄ组大鼠膈肌重量显著下降，与Ａ、Ｂ、Ｃ组相比具有显著差异（Ｐ＜０．０１），膈肌细胞萎缩明显。Ｂ组膈肌细胞超微结构变化明显。Ｃ组尽管与Ｂ组缺氧条件相同，但未观察到超微结构方面的明显变化；结论：缺氧和营养不良均可致膈肌细胞损伤，红景天对缺氧所致膈肌细胞损伤具有显著保护作用。
Objective:To observe ultrastructural changes of diaphragm induced by hypoxia and dystrophy and treate with Rasix Rhodiolae.Methods:32 wistar rats were randomly divided into groups A(control),B(hypoxic,O_2 1evle as 11 05%),C(hypoxia and treated with 10g/kg·day Rasix Rhodiloae)and D(dystrophy,1/2 normal level),and the samples of diaphragm of them were observed by electroscopy after performing 5 weeks.Results:The weight of diaphragm in group D was slightter than in group A,B and C(P<001).The structure of diaphram myocytes in group D atrophied remarkably and changes on ultastrucure of diaphragm myocytes in group B were greater than in group C although the hypoxic condition both group ws similar.Conclusions:The diapharagm myocytes of rats could be injured under condition of hypoxia and dystrophy but there are a protective effects by administering Rasix Rhodiolae.
出处
《高原医学杂志》
CAS
1998年第2期28-30,共3页
Journal of High Altitude Medicine
