摘要
目的：探讨吸入布地奈德治疗儿童哮喘的临床疗效。方法：治疗组采用干粉吸入装置都保吸入布地奈德治疗儿童哮喘８８例，持续６个月或以上，对照组６８例，用氨茶碱和／或β２受体激动剂控制哮喘发作。并对６岁以上轻中度哮喘患儿１８例，其中治疗组１０例、对照组８例患儿行第１秒最大呼气量（ＦＥＶ１）测定。结果：①两组疗效比较，治疗组优于对照组，Ｐ＜０．０１；②治疗组治疗后因哮喘住院和急诊例次比对照组显著减少；③两组共１８例６岁以上早期的轻、中度哮喘儿童，监测其肺功能，治疗１年后，原来ＦＥＶ１较低的４例有显著改善，１８例ＦＥＶ１均达到９８％～１２７％预计值，两组肺功能变化无显著性差异。
Objective:To explore the effects of inhaled glucocorticosteroid budesonide in the treatment of asthmatic childrenMethods:88 asthmatic children received the inhaled glucocorticoid budesonid delivered by turbuhaler for 6 months or longerAminophylline or/and β2agonist was given to relieve asthmatic attacks in the control groupForced expiratory volume in one second(FEV1)was determined in 18 children over 6 years of age with early mild to moderate asthma,including 10 cases of budesonide group and 8 cases control groupResults:①There was significant difference in the efficacy between the two groups(P<001)②Severe asthmatic attacks requiring hospitalization and emergent treatment were significantly reduced in budesonide group as compared to control group③FEV1 of 18 children over 6 years of age with early mild to moderate asthma in each group was followed for 1 yearLow FEV1 in 4 children either group was significantly improvedAll FEV1 in 18 cases ranged from 98% to 127% of predicted valueConclusion:Inhalation of budesonide can control asthma episodes more effectivcely than other drugs in children
出处
《新医学》
1998年第8期413-414,共2页
Journal of New Medicine
关键词
哮喘
布地奈德
药物疗法
儿童
Asthma,children Treatment Budesonide inhale
