摘要
目的：探讨急性上呼吸道感染病人单核细胞ADCC效应的变化。方法：利用细胞增殖检测单核／巨噬细胞周ADCC效应方法，测定急性上呼吸道感染病人单核细胞ADCC效应及非特异杀伤效应，并以健康人作为对照组。结果：急性上感伴发热病人单核细胞活化前ADCC（nADCC）效应高于健康对照组（P＜0．05），而活化后ADCC（sADCC）效应无明显变化；上感不伴发热病人nADCC效应低于健康对照组（P＜0．01）；上感病人无论发热与否其单核细胞非特异杀伤效应均高于健康对照组（P＜0．01）。结论：急性上呼吸道感染时发热者与无发热者ADCC效应不一致，单核细胞ApeC效应与非特异性杀伤效应功能状态可不一致。
Objective: For inquiring into the change of ADCC effect of monocyte in the patients with acuteupper respiratory tract infection (AURTI). Methods: ADCC effect and unspecialized cytotoxicity of monocytewere detected by method of CTLL2 cell proliferation. Results: The results showed that ADCC effect of monocytein AURTI Patients with fever was higher in comparison with that in normal controls (P<0. 05),but it had noobvious change when monocyte was stimulated by LPS. ADCC effect of monocyte in the patients without feverwas lower in comparison with that in normals. The unspeCialized cytotoxicity of monocyte in the patients eitherwith fever or without fever was higher than that of normal control group (P<0. 01 ). Conclusion:ADCC effectof monocyte is not equal in the patients with AURTI. ADCC effect and unspceialized cytotoxicity are differentfunctional expression of monocyte,and sometimes their functional state is not equal.
出处
《白求恩医科大学学报》
CSCD
1998年第4期353-354,共2页
Journal of Norman Bethune University of Medical Science
