摘要
目的：研究心肌缺血再灌注时人体外周血中性粒细胞（ＰＭＮ）的数量、ＰＭＮ聚集率、内皮素（ＥＴ）、脂质过氧化物（ＬＰＯ）、超氧化物歧化酶（ＳＯＤ）及过氧化氢酶（ＣＡＴ）的变化，并观察前列腺素Ｅ１（ＰＧＥ１）对心肌缺血再灌注损伤的保护作用。方法：将３６例急性心肌梗死患者随机分为２组，每组１８例。治疗组给予ＰＧＥ１加尿激酶和硝酸甘油静滴，对照组给予尿激酶和硝酸甘油静滴，于再灌注前后分别采静脉血测定上述指标。结果：心肌缺血时外周血ＰＭＮ数量无显著增多，但ＰＭＮ活性显著增强，血ＥＴ及ＬＰＯ水平增高，血ＳＯＤ和ＣＡＴ活性下降；再灌注后，ＰＭＮ数量无明显增多（Ｐ均＞０．０５），但ＰＭＮ活性进一步显著增强，ＥＴ及ＬＰＯ水平进一步显著增高，而ＳＯＤ和ＣＡＴ活性则进一步显著下降。使用ＰＧＥ１治疗后结果则与上述情况相反。结论：ＰＭＮ及ＥＴ在心肌缺血再灌注损伤过程中起重要作用，ＰＧＥ１可以抑制ＰＭＮ活性，保护ＳＯＤ和ＣＡＴ活性，减少ＥＴ及ＬＰＯ产生，减轻过氧化反应，对心肌缺血再灌注损伤有显著的保护作用。
Objective:To investigate changes in quantity and activity of polymorphonuclear leukocytes (PMN),and endothelin(ET),lipid peroxide (LPO),superoxide dismutase (SOD) as well as catalase (CAT) levels in venous blood.Meanwhile,the protective effects of prostaglandin E1(PGE1) on myocardial ischemiareperfusion injury (IRI) were also observed in patients with acute myocardial infarction (AMI).Methods:Thirtysix cases of AMI were randomly divided into treatment group (n=18) and control group (n=18).The treated group was given by venoclysis of PGE1,urokinase and nitroglycerin,while the control group was given urokinase and nitroglycerin.The above parameters in venous blood were detected before and after reperfusion.Results:The quantity of PMN was not obviously increased,but PMN activity,LPO and ET levels were markedly increased during ischemic stage.SOD and CAT activities were obviously decreased at the same time.Moreover,these changes were further enhanced during reperfusion stage.However,these changes were obviously reversed following the administration of PGE1.Conclusions:PMN and ET play important role in the pathogenesis of IRI.PGE1 can inhibit PMN activity,reduce LPO and ET production,increase SOD and CAT activities,thus showing a strong protective effect on IRI.
出处
《中国危重病急救医学》
CAS
CSCD
1998年第7期394-397,共4页
Chinese Critical Care Medicine
基金
吉林省科委青年基金
关键词
前列腺素E1
白细胞
内皮素
缺血
再灌注损伤
prostaglandin E1\ \ leukocytes\ \ endothelin\ \ ischemiareperfusion injury
