摘要
观察心肌顿抑后微血管可逆性损伤的超微结构改变，以及钙拮抗剂呋喃丙吡啶对微血管损伤是否具有保护作用．方法：建立兔心肌顿抑模型，采用镧醛灌注固定法制备电镜样品．缺血再灌注前用呋喃丙吡啶预防性给药．结果：闭塞15min再灌注15min时，血管扩张，间隙水肿，血管内外附着大量的镧颗粒．再灌注30min时损伤进一步加重，但血管膜结构完整，直至再灌注120min血管通透性损伤基本恢复正常．预防性给予呋喃丙吡啶后，闭塞15min再灌注15min，血管内皮结构完整，仅在血管腔内有镧颗粒附着在血管壁上，血管外间隙水肿减轻．结论：心肌顿抑时微血管通透性增加，血管内膜结构完整，随着再灌注时间延长，血管通透性恢复正常．缺血再灌注前预先应用呋喃丙吡啶防治可以限制微血管顿抑．
Aim: To study the ultrastructure of microvascular damage in the brief postischemic reperfused myocardium(stunned myocardium) and cardioprotective effects of calcium antagonist (1, 4-Dihydropyridines ). Methods: Ultrastructural chances of micro-vessels were observed usingcolloidal lanthanum nitrates a probe. Rabbits received 1,4-Dihydropyridines (3 mg/kg/mL iv) before occlusion. Results: Coronary microvascular permeability increased due to15 min of ischemia and 15 min of reperfusion. Lanthanumgranules were present within coronary micro-vessels. Extravascular lanthanum had widespread distribution. Whenreperfusion was extended to 120 min after 15 min of ischemia, these changes recovered by almost 80%. Conclusion: Even brief ischemia and reperfusion cause microvascular permeability temporarily without morphological damage.The improved functional recovery of microvascular stunningin rabbits pretreated with 1, 4-Dihydropyridine can be attributed to an attennuated vascular calcium overlaid duringthe brief ischemia and reperfusion.
出处
《第四军医大学学报》
1998年第4期412-414,共3页
Journal of the Fourth Military Medical University
关键词
微血管顿抑
冠状动脉缺血
硝酸镧
钙拮抗剂
stunning'
microvascular permeability
lanthanum
calcium
antagonist
