摘要
背景不同降压药物降低外周血压程度虽然相似,但对中心动脉压的影响可能存在差别。目前对降压药物,尤其β受体阻滞剂如何影响中心动脉压的研究比较少。目的探讨β受体阻滞剂酒石酸美托洛尔对高血压患者中心和外周动脉压的影响。方法选择行经桡动脉冠状动脉造影检查的原发性高血压患者50例,检查过程中随机嚼服25～50mg酒石酸美托洛尔或10mg硝苯地平,服药前与服药10min后,分别用压力传感器测量肱动脉和升主动脉压力作为外周动脉压和中心动脉压,记录心率及压力曲线。结果服用酒石酸美托洛尔后,外周动脉收缩压降低(14.2±10.4)mmHg,舒张压降低(6.4±5.3)mmHg,均较服药前明显下降(P<0.025),而中心动脉收缩压降低(6.1±3.8)mmHg,舒张压降低(1.5±1.3)mmHg,较服药前无统计学差异(P>0.025)。服用硝苯地平后,外周动脉收缩压降低(16.5±9.8)mmHg,舒张压降低(7.6±5.8)mmHg,中心动脉收缩压降低(12.3±7.8)mmHg,舒张压降低(7.0±5.6)mmHg,均较服药前明显下降(P<0.025)。两组外周动脉血压下降幅度相似(P>0.025),而中心动脉压下降幅度不同(P<0.025)。结论在与硝苯地平降外周动脉压相似的情况下,酒石酸美托洛尔降低中心动脉压水平小于硝苯地平。
Backgroud Various antihypertensive drugs decreased Peripheral arterial pressure similarly, while their effects on central arterial pressure may be at variance. The studies of the effect on central arterial pressure of antihypertensive drugs, especially the effect β adrenoreceptor blockers was paucity. Objective To investigate the effect of β adrenoreceptor blocker metoprolol tartrate on central and peripheral arterial pressure in patients with hypertension. Methods Fifty patients with primary hypertension who underwent percutaneous coronary angiography were recruited. Radial arterial and ascending aortal pressure as peripheral and central blood pressure were determined. Patients were chewing 25-50 mg metoprolol tartrate or 10 mg nifedipine during the catheterization. Results After administering metoprolol tartrate, the magnitude of decreases in peripheral arteri- al pressure were significantly （P〈0.025） , SBP（- 14.2 ± 10.4） mmHg and DBP（- 6.4 ± 5.3） mmHg （P〈0. 025）, whereas little changes were found in central arterial pressure with SBP decreased（6.1±3.8）mmHg and DBP only （1.5±1.3）mmHg （all P〉0. 025）. Both peripheral and central arterial pressure decreased significantly after administering nifedipine （P 〈 0. 025） as peripheral arterial SBP （16.5 ±9.8 ） mmHg, DBP （7.6±5.8）mmHg （P〈0. 025）, central arterial SBP（12.3±7.8 ）mmHg, central arterial DBP（7.0±5.6）mmHg （P〈0. 025）. No difference between the decreases of peripheral arterial pressure after both drugs （P〉 0. 025）. Conclusion Despite similar decrease of peripheral arterial pressure, the decrease magnitude of central arterial pressure by metoprolol tartrate was significantly smaller than that by nifedipine.
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2009年第7期645-647,共3页
Chinese Journal of Hypertension
关键词
中心动脉压
外周动脉压
高血压
Β受体阻滞剂
Central arterial pressure
Peripheral arterial pressure
Hypertension
β adrenoreceptor blockers
