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难治性丙型肝炎治疗方案的优化 被引量:4

The study of optimal treatment in patients with refractory chronic hepatitis C
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摘要 丙型肝炎慢性化几率为50%~80%^[1]。感染HCV后10~20年,至少20%患者发展为肝硬化,其中约15%肝硬化患者可发展为失代偿期肝硬化,失代偿期肝硬化10年的生存率仅为25%。HCV相关的肝细胞癌的发生率在感染30年后为1%~3%^[2],因此,丙型肝炎已成为严重的社会和公共卫生问题。
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2009年第7期488-489,共2页 Chinese Journal of Hepatology
关键词 肝炎 丙型 慢性 治疗 临床方案 Hepatitis C, chronic Therapy Clinicalprotocols
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参考文献6

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  • 2Hoofnagle JH.Course and outcome of hepatitis.Hepatology,2002,36:5 suppl 1:S21-29.
  • 3Krawitt EL,Ashikaga T,Gordon SR,et al.Peginterferon alfa-2b and ribavirin for treatment-refraotory chronic hepatitis C.J Hepatol,2005,43:243-249.
  • 4Maans MP,McHutchison JG,Gordon SC,et al.Peginterferon alfa2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C:a randomised trial.Lancet,2001,358:958-965.
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  • 6Reichard O,Norkrans G,Frydén A,et al.Randomised,double-blind,placebo-controlled trial of interferon alpha-2b with and without ribavirin for chronic hepatitis C.The Swedish Study Group.Lancet,1998,351:83-87.

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  • 1吴亮,王颖,田德英.聚乙二醇干扰素α-2a联合利巴韦林治疗丙型肝炎70例临床观察[J].中华传染病杂志,2008,26(9). 被引量:8
  • 2丙型肝炎防治指南[J].临床肝胆病杂志,2004,20(4):197-203. 被引量:733
  • 3Hoofnagle JH. Course and outcome of hepatitis[J]. Hepatology, 2002,36(5 suppl) :S21 - 29.
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  • 5VELDT B J, HEATHCOTE E J, WEDEMEYER H, et al. Sus- tained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis [ J ]. Ann In- tern Med, 2007, 147(10): 677-684.
  • 6FERENCI P, FRIED MW, SHIFFMAN ML, et al. Predicting sustained viroiogical responses in chronic hepatitis C patients treated withpeginterferon alfa - 2a { 40 KD )/ribavirin [ J ]. J Hepatol, 2005, 43(3) : 425 -433.
  • 7FREI P, LEUCHT AK, HELD U, et al. Elderly age is not a negative predictive factor for virological response to therapy with pegylated interferon -c and ribavirin in chronic hepatitis Cvirus patients[J]. Liver Int, 2014, 34(4) 551 -557.
  • 8FEDERICO A, MASARONE M, ROMANO M, et al. Rapid virological response represents the highest prediction factor of response to antiviral treatment in HCV- related chronic hepatitis = a multicenter retrospective study[ J]. Hepat Mon, 2015, 15(6)= 1 -5.
  • 9MARCELLIN P, CHEINQUER H, CURESCU M, et al. High sustained virologic response rates in rapid virologic response patients in the large real-world PROPHESYS cohort confirm results from randomized clinical trials [ J ]. Hepatology, 2012, 56(6) = 2039 -2050.
  • 10魏来.慢性丙型肝炎治疗:更多的机遇,更多的挑战[J].中华肝脏病杂志,2009,17(7):481-483. 被引量:5

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