摘要
为使山西省卫生防疫站研制的两种类型饮水补碘器安全用于人群，对其加碘后的饮水进行了大鼠９０天喂养，小鼠骨髓嗜多染红细胞微核及睾丸染色体畸变试验，结果表明：两类补碘器加碘后的饮水比对照组自来水水碘高５～６倍，大鼠尿碘明显增高，是对照组的３～５倍（Ｐ＜０．０１）；大鼠生长曲线、食物利用率、尾血血象、肝功能、肾功能、Ｔ３值、Ｔ４值、ＴＳＨ值、脏体比、脏器组织切片等指标均与对照组无显著性差别；两项遗传毒性指标也未显示致突变作用。现场应用安全、有效、方便。
To be safely used for human,two types of iodinesupplement device for drinking water made by Shanxi Provincal sanitary and antiepidemic station were studied with 90day feeding test in rats,bone marrow polychromatic erythrocytes micronucleus test and testicle chromosome aberration test in miceThe results showed that the iodine content of water added with iodinesupplement device was 5￣6 times higher than that of controlThe iodine in the urine of rats showed a significant increasing tendency compared with control group,it was 3￣5 times of that in control groupThere were no significant differences in the indexes,such as the growthcurvilinear,rate of foodutilized,peripheral hemogram,hepatorenal function,T3,T4,TSH value,ratio between viscera and body and findings in sections of organic tissues of rats between test groups and control groupTwo indexes of genotoxicity displayed no mutagenicitiesPractical application was safe,effective and convenientSo it was safe for the iodinesupplement device for drinking water to be used for human
出处
《环境与健康杂志》
CAS
CSSCI
CSCD
北大核心
1998年第4期151-153,共3页
Journal of Environment and Health
关键词
补碘器
饮水
遗传毒性
加碘
安全性
Iodinesupplement device Iodine in drinking water Genotoxicity
