摘要
目的:探讨羊膜移植联合微量曲安奈德局部注射治疗复发性翼状胬肉的疗效及安全性。方法:对280例(310眼)复发性翼状胬肉显微切除联合羊膜移植,随机对其中145例(160眼)作为治疗组,术后3-5 d角膜创面修复后注射曲安奈德(0.1 ml,4 mg),术后4周再局部注射同样剂量曲安奈德1次,其余135例(150眼)作为对照组,局部不注射曲安奈德。术后随访观察4-24月。结果:治疗组145例(160眼)中151眼角膜光滑透明,或仅留云翳、羊膜结膜化,无明显纤维血管组织增生。9眼复发,复发率为5.6%。对照组135例(150眼)中25眼复发,复发率为16.7%,两组有统计学差异(P<0.01)。所有病例无眼压增高,角膜上皮修复迟滞、感染和羊膜植片排斥等并发症。结论:羊膜移植联合曲安奈德治疗复发性翼状胬肉有效、安全,二者有协同相加作用,能明显降低术后复发率。
Objective. To investigate the curative effect and safety of amniotie membrane transplantation combined with triamcinolone acetonide local injection for the treatment of recurrence pterygium. Methods： A total of 280 cases （310 eyes） of relapse pterygium were treated with micro-sugical operation and amniotic membrane transplantation, and of all the cases involved, 145 cases （160 eyes） were treated with local injection of triamcinolone acetonide （0.1 ml, 4 mg） after operation. The other 135 cases （150 eyes） without triamcinolone acetonide injection were set as control group. All the cases were followed up for 4-24 months. Results： In 151 eyes of the 145 cases （160 eyes）, cornea was smooth and transparent, or left only some nebulae, the amniotic membrane was covered with conjunctiva, and no obvious fiber vessel proliferation was found. Recurrence was noted in 9 eyes, the recurrence rate was 5.6%, which is much less than that of the control group （16.7%, P〈0.01）. No serious complications were found in all the cases. Conclusion： It was an effective and safe method to treat pterygium by amniotic membrane transplantation combined with triamcinolone acetonide injection, and the treatment showed synergetic effects and could reduce the recurrence rate obviously.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2009年第4期533-536,共4页
Medical Journal of Wuhan University
关键词
羊膜
移植
复发性翼状胬肉
曲安奈德
Amniotic Membrane
Transplantation
Recurrence Pterygium
TriamcinoloneAeetonide
