摘要
以N-烯丙基咔唑为原料,经Friedel-Crafts酰化反应、成肟和酯化,得到目标化合物。通过正交试验研究了关键步骤Fridel-Crafts酰化,得到最佳反应条件:N-烯丙基咔唑用量为0.020mol,催化剂与原料摩尔比1.10,反应物摩尔比1.15,25℃下反应4h,产率可达94.2%。目标产物的结构通过IR、UV、1HNMR和元素分析测试技术进行表征,并与商品IrgOXE-2的光引发性能进行了比较。
1-（ 6-Benzoyl-9-allyl-9. H.- carbazol-3-yl）-butane-l-one oxime O-ethyrate was synthesed by Friedel-Crafts acylation, oximation and esterifieation from N-allylcarbazole. As the key step of the synthesis, the optimal operation of Friedel-Crafts acylation was established by orthogonal experiment. For the 0. 02 mol N-allylcarbazole, molar ratio of catalyst to reactants n （AICl3 ）/n （N-allylcarbazole） was 1.10, molar ratio of reactants n（ benzoic eloride ）/n（ N-allylcarbazole ） was 1.15, and the reaction was carried out at 25 ℃ for 3 h. The average yield was 94. 2%. The structure of the target compound was characterized by 1H NMR, UV, IR and elemental analysis. Photoinitiability of the compound was investigated comparing with the commercial product.
出处
《应用化学》
CAS
CSCD
北大核心
2009年第7期762-765,共4页
Chinese Journal of Applied Chemistry
关键词
咔唑肟酯
合成
正交试验
光引发性
carbazol oxime ester, synthesis, orthogonal experiment, photoinitiability
