摘要
目的测定老年脑出血患者血浆内皮素（ＥＴ）、心钠素（ＡＮＰ）浓度并探讨其临床意义。方法以放射免疫法测定老年和非老年健康人；老年及非老年脑出血患者不同时期血浆ＥＴ及ＡＮＰ水平。结果老年脑出血患者急性期血浆ＥＴ为１４８．１８ｎｇ／Ｌ，ＡＮＰ为５７．３３ｎｇ／Ｌ，较健康对照组明显升高（分别为Ｐ＜０．０１及Ｐ＜０．０５）。恢复期与对照组比较无明显差异。同期测定的非老年脑出血患者血浆ＥＴ和ＡＮＰ浓度与老年患者差异无显著意义（Ｐ＞０．０５），直线相关分析表明，老年脑出血患者急性期血浆ＥＴ与ＡＮＰ之间呈明显正相关。结论脑出血患者血浆ＥＴ、ＡＮＰ浓度的升高与脑出血的发生。
bjective To determine the levels of plasma endothelin(ET) and atrial natriuretic peptide(ANP) in aged patients with cerebral hemorrhage(CH) and to explore their clinical significance and the relationship between ET and ANP. Methods Plasma levels of ET and ANP were measured by radioimmunoassay at different stages in aged and non aged patients with cerebral hemorrhage and aged healthy persons. Results The results showed that plasma ET and ANP Levels in aged patients with CH were significantly higher than those in the healthy control group. The concentrations of plasma ET and ANP at the acute stage of CH were 148 18ng/L( P <0 01) and 57 33ng/L( P <0 05), respectively. The difference in the levels of plasma ET and ANP between the non aged and aged patiente were not significant( P >0 05). The levels of plasma ET showed a marked positive correlation with ANP in aged CH. Conculusions It is suggested that the elevation of ET and ANP levels may contribute to the pathogenesis and development of CH.
出处
《实用老年医学》
CAS
1998年第3期108-109,共2页
Practical Geriatrics
关键词
脑出血
内皮素
心钠素
血浆
病理
Cerebral hemorrhage Endothelin Atrial natriuretic peptide
