摘要
目的研究低通量聚砜膜对慢性血液透析患者血清炎症因子、超敏C反应蛋白(hsCRP)、脂蛋白(a)[Lp(a)]和β2微球蛋白(β2MG)水平的影响。方法以病情稳定、长期行血液透析的27例患者为研究对象,留取透析前、透析中2h、透析后血清和透析水样,测定血清Lp(a)、β2MG、白细胞介素(IL)-1β、IL-6和hsCRP水平,并测定透析水样中的内毒素水平。结果透析前、透析中2h和透析后透析水样中的内毒素水平及患者血清IL-1β、IL-6、hsCRP、Lp(a)和β2MG水平差异均无统计学意义(P>0.05)。结论低通量聚砜膜对血液透析患者一次治疗过程中的血清炎症因子、hsCRP、Lp(a)和β2MG水平没有影响。
Objective To explore the effect of low-flux polysulphone membranes on the serum levels of inflammatory cytokines, hyper-sensitivity C reactive protein （hsCRP）, lipoprotein （a） [ Lp （a） ], and β2 microglobumin （β2MG） in hemodialysis patients. Methods The blood samples and dialysate samples were collected at pre-dialysis, 120 minutes later during the session, and post-dialysis in 27 stable hemodialysis patients. Variables determined included serum Lp （a）, hsCRP, interleukin （IL） -1β, IL-6, and β2MG. The endotoxin levels were also detected. Results There were no significant changes either in endotoxin level of dialysate or in all variables tested during one session （P 〉 0. 05）. Conclusion Low-flux polysulphone membrane has no effects on serum Lp （a）, hsCRP, IL-1β, IL-6, and β2MG during one session in hemodialysis patients.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2009年第3期362-364,共3页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金(30700373)~~
关键词
低通量聚砜膜
血液透析
炎症因子
超敏C反应蛋白
脂蛋白(a)
Β2微球蛋白
low-flux polysulphone membranes
hemodialysis
inflammatory eytokines
hyper-sensitivity C reactive protein
lipoprotein （a）
β2 mieroglobumin
