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子痫前期外周血免疫相关基因的差异表达 被引量：1

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摘要 目的 了解子痫前期患者外周血免疫相关基因的差异表达，探索其与子痫前期发病的关系。方法选择4例重度子痫前期患者为研究对象，以4例正常妊娠妇女为对照，应用基因芯片技术检测两组孕妇外周血差异基因表达谱，了解子痫前期外周血免疫相关基因的异常表达。结果在所检测的21000个基因中，出现2次重复一致差异表达的免疫相关基因共有33个，子痫前期组差异表达上调基因23个，下调基因10个。结论免疫相关基因的差异表达可能是子痫前期发病的原因之一。 Objective To investigate the differential expression of immunity - related genes in peripheral blood leucocytes between preeelampsia and normal pregnancy cases, and to explore the pathogenesis of preeclampsia. Method The differential gene expression files of 4 severe preeclampsia and 4 normal pregnancy cases were studied using cDNA array technique in order to identify the differential expression of immunity - related genes. Results 33 differentially expressed immunity - related genes had the concordance in at least 2 cases among total 21000 genes. 23 genes were up - regulated and 10 were down - regulated. Conclusions Differential expression of immunity - related genes in peripheral leucocytes from preeclampsia may be responsible for the molecular mechanism of preeclampsia .
作者 孙波 郑桂琴 赵卫华 高素清 张为远
机构地区 广东省深圳市第二人民医院妇产科 首都医科大学附属北京妇产医院
出处 《浙江临床医学》 2009年第6期570-572,共3页 Zhejiang Clinical Medical Journal
基金 深圳市科技计划项目（项目编号200702072）
关键词 子痫前期 差异表达 寡核苷酸序列分析 基因 免疫 Preeclampsia Differential expression Oligonucleotide array sequence analysis Gene Immunity
分类号 R714.245 [医药卫生—妇产科学] R581.1 [医药卫生—内分泌]
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参考文献8

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同被引文献21

  • 1李东红,杨梦庚.胎盘与妊高征发病的关系[J].中华妇产科杂志,1994,29(11):687-689. 被引量：22
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  • 6Zhu XM, Han T, Sargent IL, et al. Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies[J].Am J Obstet Gynecol, 2009,200 (6) : 661.
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浙江临床医学
2009年 第6期

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