摘要
目的探讨老年糖尿病患者尿路感染病原菌的分布情况及耐药特征,为临床医生提供尿路感染用药依据。方法对2006年1月至2008年11月246例老年糖尿病患者尿路感染病原菌进行鉴定和体外药敏试验,细菌鉴定按《全国临床检验操作规程》进行;药敏试验采用琼脂扩散法(K-B)进行。结果分离率在前5位的病原菌依次为大肠埃希菌(58.9%)、粪肠球菌(10.2%)、肺炎克雷伯菌(6.9%)、铜绿假单胞菌(6.1%)、金黄色葡萄球菌(5.3%)。大肠埃希菌对亚胺培南、美罗培南、阿米卡星和呋喃妥因的敏感率在81.4%～100.0%之间;粪肠球菌对万古霉素、呋喃妥因的敏感率在88.0%～100.0%之间。病原菌对以往用于治疗泌尿系感染的常用药物,如庆大霉素、环丙沙星等已产生较高的耐药性(>50.0%)。结论老年糖尿病患者易罹患尿路感染,其主要病原菌为大肠埃希菌和粪肠球菌,病原菌耐药性较强,应及早进行预防和控制。
Objective To determine distribution of pathogens and resistance characteristic in urinary tract in fections in aged patients with diabetics and offer scientific basis for reasonable usage of antibiotics. Methods Patho- genic bacteria isolated from specimens of 246 cases with urinary tract infections were identified and drug susceptibili- ty tests were performed from Jan 2006 to Nov 2008 in our hospital. Results The first 5 were Escherichia coli （58.9 % ） , Enterococcus faecalis （10.2 ~ ） , Klebsiella pneumoniae （6.9 % ） , Pseudomonas aeruginosa（6.1 ~ ）, Staphy- lococcus aureus （5.3%）. The isolates were fairly susceptible to Escherichia coli , Imipenem,Meropenem,Amikacin and Nitrofurantoin（81.4 % - 100.0 % ）, while the sensitivity of Enterococcus faecalis to Vaneomycin and Nitrofurantoin is between 88.0% and 100.0%, and pathogenic bacteria showed higher drug resistance to the other common antibiotics,, such as gentamicin, ciprofloxacin（〉 50.0 %）. Conclusion The aged patients with diabetics easily suffer from urinary tract in/ections. The main pathogenic bacteria were Escherichia coil and Enterocoecus faecalis,and the drug resistance of pathogenic bacteria is higher. Therefore, we should take preeautional measures to control the urinary tract infections in diabetics.
出处
《检验医学与临床》
CAS
2009年第13期1048-1049,1051,共3页
Laboratory Medicine and Clinic
关键词
老年糖尿病
尿路感染
病原菌
耐药性
old age diabetes
urinary tract infection
pathogenic bacteria
drug resistance
