摘要
目的探讨血管紧张素II受体拮抗剂——厄贝沙坦对糖尿病大鼠肾脏血管内皮生长因子(VEGF)表达的影响。方法采用高脂饮食加小剂量链脲菌素(STZ)一次性腹腔注射建立2型糖尿病大鼠模型,光镜及电镜行肾脏形态学检查;VEGF免疫组化染色观察VEGF水平变化。结果2型糖尿病大鼠肾脏VEGF表达明显高于正常对照组(均P<0.01),同时大鼠肾脏出现糖尿病肾病的病理变化;厄贝沙坦干预后,肾组织VEGF表达较2型糖尿病组降低(P均<0.01),同时肾脏病理变化也得到明显改善。结论厄贝沙坦可能通过抑制肾脏VEGF表达,延缓糖尿病肾病的发生。
Objective To investigate the influences of angiotensin Ⅱreceptor antagonists on renal expression of VEGF in type 2 diabetic rats. Methods Type 2 diabetes model was induced by long-term high-fat feeding accompanied with intraperitoneal injection of streptozotocin （STZ）. The morphological changes of kidney tissue were detected by light and electron microscopy. Glomerular VEGF protein synthesis were evaluated by immunohistochemical staining. Results The main features of the diabetic renal parenchyma were observed in type 2 diabetic rats and VEGF protein was higher in type 2 diabetic rats than in control rats （ P 〈 0.01 ）. The expression of VEGF protein was decreased after treatment with irbesartan （ P 〈 0.01 ） , while the renal damage was significantly improved. Conclusion The down regulation of expression Of VEGF induced by angiotensin II receptor antagonists treatment might be related to progress of diabetic nepbropathy.
出处
《疑难病杂志》
CAS
2009年第7期385-387,I0001,共4页
Chinese Journal of Difficult and Complicated Cases
基金
河北省卫生厅科研基金项目(No.06176)
关键词
糖尿病
2型
糖尿病肾病
厄贝沙坦
血管内皮生长因子
Type 2 diabetes mellitus
Diabetic nephropathy
Irbesartan
Vascular endothelial growth factor
