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L-OHP联合5-FU/CF方案不同给药方法治疗晚期大肠癌的疗效观察 被引量:1

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摘要 目的比较奥沙利铂(L-OHP)联合氟尿嘧啶(5-Fu)/甲酰四氢叶酸(CF)方案的不同给药方法治疗晚期大肠癌的疗效和不良反应。方法32例晚期大肠癌患者均可参加疗效评价,A组(15例):L-OHP 130mg/m^2、静滴、第1d,CF 200mg/m^2、静滴2h、第1-5d,5-FU 375-400mg/m^2、静滴、第1-5d、4-6h,每3周重复,3周为1个周期。B组(17例):L-OHP 85mg/m^2、静滴、第1d,CF 200mg/m^2、静滴2h、第1-2d,5-FU 500mg/m^2、静推,再以600mg/m^2持续泵入22h、第1-2d,每2周重复,4周为1个周期。结果A组CR1例,PR6例,总有效率为46.6%。B组CR 1例,PR7例,总有效率41.1%。结论L-OHP联合5-FU/CF不同的给药方法治疗晚期大肠癌疗效相近,毒副作用少。
出处 《河南职工医学院学报》 2009年第3期234-236,共3页 Journal of Henan Medical College For Staff and Workers
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  • 1Tournigand C,Andre T,Achille E,et al.FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer:a randomized GERCOR study[J].J Clin Oncol,2004,22:229 -237.
  • 2Xiong HQ,Ajani JA.Treatment of colorectal cancer metastasis:the role of chemotherapy [J].Cancer Metastasis Rev,2004,23(1 -2):145 -163.
  • 3Kohne CH,van Cutsem E,Wils J,Bokemeyer C,et al.Phase Ⅲ study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer:European Organization for Research and Treatment of Cancer Gastrointestinal Group Study 40986 [J].J Clin Oncol.2005,23 (22) :4856 - 4865.
  • 4Martin MJ.Current stage-specific chemotherapeutic options in colon cancer [J].Expert Rev Anticancer Ther,2005,5 (4):695 -704.
  • 5Grothey A,Deschler B,Kroening H,et al.Phase Ⅲ study of bolus 5-fluorouracil (5-FU)/folinic acid (FA) (Mayo) vs weekly high-dose 24h 5-FU infusion/FA + oxaliplatin (OXA)(FOLFOX) in advanced colorectal cancer (ACRC) [J].Proc Am Soc Clin Oncol,2002,21 :abstr 512.
  • 6Kohne CH,Cutsem VE.Wils JA et al.Irinotecan improves the activity of the AIO regimen in metastatic colorectal cancer:Results of EORTC GI Group study 40986 [J].Proc Am Soc Clin Oncol,2004,23:abstr 1018.
  • 7Saltz LB,Cox JV,Blanke C,et al.Irinotecan plus fluorouracil and leucovorin for metastatic Colorectal cancer.Irinotecan Study Group[J].N Engl J Med,2000,343(13) :905 -914.
  • 8de Gramont A,Figer A,Seymour M,et al.Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer[J].J Clin Oncol,2000,18(16) :2938- 2947.
  • 9de Gramont A,Bosset JF,Milan C,et al.Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer:a French intergroup study[J].J Clin Oncol ,1997,15(2) :808 -815.
  • 10Cunningham D,Humblet Y,Siena S,et al.Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer[J].N Engl J Med,2004,351 (4) :337- 345.

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