摘要
创伤性脑损伤(TBI)平战时常见,残死率极高。TBI病理进程中非感染性炎症反应(简称TBI炎症反应)起重要作用,直接影响TBI的预后和转归。由于TBI炎症反应的发生机制迄今不明,临床仍缺乏有效的干预手段。最新研究显示:Toll样受体(TLRs)可介导非感染性炎症反应,其家族成员TLR2/4(TLR2或TLR4)与某些中枢疾患的非感染性炎症反应相关。目前有关TLR2/4在TBI炎症反应中作用与调控的研究开始受到学者注意,国内外研究报道极少,有望成为一个新的研究热点。本文对此予以评述。
Traumatic brain injury （ TBI ） is a common disease among peace-time and war time injuries, with high morality and morbidity. The non-infective inflammatory reactions play an important role in the pathological process in TBI which affect directly the prognosis and turnover of TBI. The mechanism of these inflammatory reac- tions is unknown, and so the clinical practice is still lack of interventional strategies to cope with TBI. The newest research demonstrates that the toll-like receptors （TLRs） mediates non-infective inflammatory reactions and their family members TLR2/4 （ TLR2 or TLR4 ） are associated with non-infective inflammation in some diseases in central neuvous system. Recently the studies on the effect and mechanism of TLR2/4 in the TBI have been noted. The re- lated studies are rarely reported nationally and internationally. It is possible for TLR2/4 to be a new research focus. The problems relating to TLR2/4 are discussed and reviewed in this paper.
出处
《创伤外科杂志》
2009年第4期289-292,共4页
Journal of Traumatic Surgery
关键词
颅脑损伤
炎症反应
受体
brain injury
inflammatory reaction
receptors
