摘要
目的:探讨胃癌组织中Egr-1 mRNA表达水平与临床病理关系。方法:用RT-PCR方法,测定本科35例胃癌患者中胃癌、切缘正常胃组织Egr-1 mRNA的表达水平。病理检查确定胃癌组织病理类型、分化程度及淋巴结转移情况。分析Egr-1 mRNA表达水平与临床病理关系。结果:胃癌组织中Egr-1 mRNA表达水平明显高于正常胃组织(P<0.01);低分化胃癌中Egr-1 mRNA表达水平高于高分化胃癌(P<0.01);有淋巴结转移组表达水平高于无淋巴结转移组(P<0.01)。结论:Egr-1基因表达与胃癌发生发展及转移有密切相关。
Objective：To study the relationship between Egr-1 mRNA expression and clinical pathology in gastric cancer. Methods：In thirty-five patients with gastric cancer, expression of Egr-1 mRNA in cancerous tissue and at normal cutting edges was detected with semi-quantitative RT-PCR. Clinicopathologieal types, grading of differentiation as well as lymph noda metastasis of these lesions were investigated. Results：the expression level of Egr-1 mRNA was more likely to be higher in gastric cancer than in normal tissue （ P 〈 0. 01 ）, in poor-differentiated than that in welldifferentiated gastric： cancer（ P 〈0.01 ）, and in lesions with lymph node metastasis than in those with not（P 〈0. 01 ）. Conclusion：The expression of Egr-1 mRNA may have a close relation with occurrence, development and metastasis of gastric cancer.
出处
《广州医学院学报》
2009年第1期21-23,共3页
Academic Journal of Guangzhou Medical College
基金
江苏省常州市武进科委立项资助
