摘要
目的通过对根治或改良根治术后乳腺癌出现肺转移患者的临床资料的回顾性分析,初步探讨影响其肺转移的因素。方法收集1995年至2006年在我院进行治疗临床资料完整的乳腺癌患者568例,通过电话随访、门诊复查,完成478例随访,通过纳入标准筛选,入选乳腺癌患者347例。从中选择经过根治术或改良根治术后的,术后肺转移的乳腺癌患者58例。结果经Logist多因素分析得到结论:乳腺癌术后肺转移均与与肿块大小,及术后辅助化疗相关;肺转移还与ER状态,病理结果以及肿瘤的临床分期相关,ER阴性,浸润性癌及临床分期晚的患者易出现术后肺转移,而与年龄,月经状态,肿块的部位,Her-2的表达,术后放疗疗,孕激素受体及肿瘤的组织学分级无明显相关。结论肿块大,淋巴转移≥4,ER阴性,TNM分期晚的浸润性癌患者更容易肺转移,坚持采用化疗,采用对肺转移敏感的化疗药物,注意肝肺脏器随访。
Objective To discuss factors which influence breast cancer lung metastasis after mastectomy. Methods The clinical data of breast cancer patients who underwent treatment in our hospital from 1995 to 2005 was collected, complete the follow-up of 354 cases by telephone and out-patient review, after choosing the cases which after mastectomy, get 58 cases with lung metastasis for analysis. Result The lung metastases are related with tumor size, and postoperative adjuvant chemotherapy related,with ER status, pathology results and clinical stages of tumor related, ER negative, invasive carcinomas and clinical staging of patients with late emergence of the first postoperative lung metastases？and with age, menstrual status, tumor site, Her-2 expression after chemotherapy, progesterone by body and the tumor histological grade was no significant correlation？Conclusion ER-negative, TNM staging late invasive cancer patients more vulnerable to lung metastasis, insist the use of chemotherapy for lung metastases using chemotherapysensitive, pay attention to follow-up of hepatopulmonary organ.
出处
《医学信息》
2009年第7期1213-1215,共3页
Journal of Medical Information
