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蛋白质折叠与淀粉样沉积的产生

Protein Folding and Formation of Amyloid Deposition
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摘要 蛋白质是生物体内一切功能的执行者,而蛋白质正确折叠则是发挥其生理功能的一个重要前提条件。近年来研究发现,蛋白质的错误折叠可以形成淀粉样沉积进而导致一些疾病的产生。探讨了蛋白质折叠和淀粉样纤维产生的机制。 Proteins take center stage in directing the working of living cell,but the folding of protein plays an important role in achieving their biological function.In recent years,a number of diseases are believed to be caused by amyloid deposition results from protein misfolding.In the paper we discuss the mechanisms of protein folding and the formation of amyloid fibrils.
作者 王莉衡 钦传光 尚晓娅 牛卫宁 WANG Li-heng;QIN Chuan-guang;SHANG Xiao-ya;NIU Wei-ning(Faculty of Life Sciences,Northwestern Polytechnical University,Xi'an 710072,China)
机构地区 西北工业大学生命科学院
出处 《化学与生物工程》 CAS 2009年第6期11-14,共4页 Chemistry & Bioengineering
基金 国家自然科学基金资助项目(20672086) 西北工业大学科技创新基金资助项目(2008KJ02038)
关键词 蛋白质折叠 蛋白质错误折叠 淀粉样沉积 分子伴侣 神经退行性疾病 protein folding protein misfolding amyloid deposition molecular chaperone neurodegenerative disease
分类号 Q51 [生物学—生物化学]
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参考文献18

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共引文献35

化学与生物工程
2009年 第6期

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