摘要
目的探讨端粒重复序列结合因子1(Telomeric repeat binding factor 1,TRF1)在食管病变中的表达及其临床意义。方法采用免疫组化ABC法检测60例食管鳞状细胞癌、30例食管上皮内瘤变和20例食管正常组织中TRF1的表达,并探讨与食管癌临床病理特征之间的关系。结果在正常上皮组织、上皮内瘤变和食管鳞癌组织中,TRF1的阳性表达率分别为为95%、63.3%和21.7%。食管鳞癌组织中,TRF1的表达与浸润深度和肿瘤长度呈负相关(0>rs>-1,P<0.05)。结论TRF1在食管癌组织中表达异常降低,提示TRF1与食管癌的发生、发展有密切的关系,检测TRF1的表达可能成为判断食管鳞癌生物学行为的重要指标。
Objective To investigate the expressions of Telomeric repeat binding factor 1 （ TRF1 ） in esophageal squamous cell carcinomas （ESCC） and their clinical significance. Methods The expressions of TRF1 were detected by the immunohistochemical method in 60 cases of esophageal squamous cell carcinomas （ ESCC）, 30 intraepithelial neoplasia and 20 normal esophageal mucosal epithelia. It＇s relations with the clinicopathologic features of ESCC were analyzed. Results The rates of positive expressions of TRF1 in normal esophageal mucosal epithelium, intraepithelial neoplasia and ESCC were respectively 95% ,63.3% and 21.7%. The expressions of TRF1 were negatively correlated with the depth of tumor invasion and the length of tumer in ESCC （0 〉 rs 〉 - 1,P 〈 O. 05）. Conclusions Low expres- sion of TRF1 were found in ESCC. It may play an important role in the carcinogenesis and aggression in ESCC. TRF1 may be a useful marker for evaluating the biological behaviors of ESCC.
出处
《医学信息（内.外科版）》
2009年第5期441-444,共4页
Medical Information Operations Sciences Fascicule
基金
皖南医学院中青年科学基金(WK200701F)
关键词
端粒重复序列结合因子1
免疫组织化学
食管鳞癌
telomeric repeat binding factor 1 （TRF1）
immunohistochemistry
esophageal squamous cell carcino- mas （ESCC）
