摘要
目的:观察七叶皂苷钠对重型颅脑创伤患者血清神经元特异性烯醇化酶(NSE)和S-100β蛋白含量的影响。方法:48例入选患者随机分为对照组和治疗组各24例。治疗组在常规治疗基础上给予七叶皂苷钠10mg,ivd,qd,连用7d。对照组除七叶皂苷钠外其他治疗完全相同。分别在治疗前后不同时间点检测患者血清NSE和S-100β含量,3个月后行GOS评分,然后对所得资料进行统计学分析。结果:治疗后治疗组血清NSE和S-100β含量明显低于对照组(P<0.05)。治疗组GOS评分显著好于对照组(P<0.05)。结论:七叶皂苷钠能降低重型颅脑创伤患者血清NSE和S-100β含量,有改善预后的可能。
Objective： To observe the effect of aescine sodium on the serum neuron specific enolase （NSE） and S-100β of the patients with severe traumatic brain injury （sTBI）. Method： Fourty eight patients were divided into two groups randomly,each group was 24 cases. The control group was used routine therapy and the therapeutic group was used the routine therapy plus aescine sodium 10 mg ivd, qd for 7 days. The contents of serum NSE and S-100β of all patients were measured at different time, respectively. Glasgow outcome scale （GOS） of all patients were determined after 3 months.of therapy. Then the data were analyzed statistically. Result： After different times of treatment, compared with the control group, the contents of serum NSE and S-100β in the therapeutic group were decreased significantly （ P 〈 0.05 ）. The GOS were significantly better in therapeutic group versus control group （P 〈 0.05 ）. Conclusion： Aescine sodium can decrease the contents of serum NSE and S-100βof patients with sTBI, and improve their outcome probably.
出处
《中国药师》
CAS
2009年第7期925-926,共2页
China Pharmacist
