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急性冠脉综合征血清MMP-2,MMP-9及hs-CRP水平的检测及其临床意义 被引量：3

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摘要 目的:观察急性冠脉综合征患者外周静脉血清基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)、超敏C反应蛋白(hs-CRP)水平并评价其临床意义。方法:选取急性冠脉综合征患者53例为ACS组,其中急性心肌梗死(AMI)28例,不稳定型心绞痛(UA)25例。用酶联免疫吸附法(ELISA)检测血清MMP-2,MMP-9水平,用免疫散射比浊法检测血清hs-CRP。另选稳定型心绞痛组(SA)28例、正常对照组30例作为对照。结果:ACS组血清MMP-2,MMP-9,hs-CRP的水平高于SA组(P<0.05)及对照组(P<0.01)。AMI组血清MMP-2,MMP-9,hs-CRP的水平显著高于UA组(P<0.05)。ACS组患者血清MMP-9与hs-CRP水平呈正相关,MMP-2与hs-CRP无明显相关性。AMI组患者血清hs-CRP与cTnI水平呈正相关(r=0.401,P<0.05)。结论:MMP-2,MMP-9在ACS中的高表达与急性冠脉综合征的发生有关,可作为预测动脉粥样斑块不稳定或破裂的血清学指标,其水平有利于冠心病患者的危险分层。联合检测血清MMP-2,MMP-9与hs-CRP可能成为一种有效的判断斑块稳定性、预测急性心血管事件发生的临床指标。
作者 胡开宇 蔡雪黎 张怀勤 计光 王忠永
机构地区 温州医学院附属第一医院心血管内科 温州医学院附属第一医院实验诊断中心
出处 《温州医学院学报》 CAS 2009年第3期278-280,共3页 Journal of Wenzhou Medical College
关键词 冠脉综合征 基质金属蛋白酶-2 基质金属蛋白酶-9 超敏C反应蛋白
分类号 R541 [医药卫生—心血管疾病]
  • 相关文献

参考文献6

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共引文献23

同被引文献27

  • 1李江,赵水平,彭道泉,周宏年.冠心病患者血清sCD40L和MMP-9的变化及相关性[J].中南大学学报（医学版）,2004,29(5):517-520. 被引量：14
  • 2张梅,黄体钢,周丽娟,张一芝,张伟函.急性冠状动脉综合征患者MMP-9、MMP-2的临床意义[J].中国心血管杂志,2006,11(5):334-337. 被引量：17
  • 3郝冰,孟晓萍,杨东华,王莉,郭昊.普罗布可对冠心病患者血清中MMP-2的抑制作用[J].吉林大学学报（医学版）,2007,33(3):559-561. 被引量：15
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引证文献3

二级引证文献26

温州医学院学报
2009年 第3期

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