摘要
目的从临床及病理学两个层面分析HBeAg阴性与HBeAg阳性慢性乙型肝炎(以下简称慢乙肝)的特征,比较其血清生化指标变化、病毒载量水平及肝组织病理改变的特点。方法选取慢性乙型肝炎(CHB)患者67例,行超声引导下快速肝穿刺活检,并分别检测血清ALT、AST、TBil、A/G及HBVDNA定量,将结果进行对比分析。结果67例CHB患者中,HBeAg阴性24例(35.82%),阳性43例(64.18%)。HBeAg阴性慢乙肝与HBeAg阳性慢乙肝比较,阴性组血清ALT水平升高较阳性组明显,差异有统计学意义(P<0.05);其血清AST、TBil、A/G两组比较均无明显差异。两组HBVDNA定量水平比较,阴性组低于阳性组,差异有统计学意义(P<0.05)。两组肝组织病理学改变无明显差异(P>0.05)。结论HBeAg阴性慢乙肝患者存在不同程度肝功能损害和病理损伤,应给予高度重视,有条件时应进行肝穿刺活检,以便及早诊断和治疗。
Objective To characterize the clinical and pathological features of HBeAg （ - ） and （ ＋ ） chronic hepatitis B patients by comparing serum biochemistry indices, virus load and liver pathology. Methods In 67 chronic hepatitis B （CHB） patients, liver biopsy, ALT, AST, TBil, A/G and HBVDNA were conducted respectively. The results were then analyzed between HBeAg （ - ） and （ ＋ ） groups. Results Among 67 patients, 24 were HBeAg （ ＋ ） （35.82%）, while 43 HBeAg （ - ） （64. 18% ）. Serum ALT level was significantly high in HBeAg （ - ） group than HBeAg （ ＋ ） group （P 〈 0. 05 ）. No significant differences were observed in serum AST, TBil and A/G. HBVDNA load was significantly lower in HBeAg （ - ） group than HBeAg （ ＋ ） group （ P 〈0. 05 ）. The liver pathologic observation found no obvious differences within two groups （P 〉 0. 05）. Conclusion HBeAg （ - ） CHB patients have varied damages to liver function and histology; they should be paid enough attentions. If possible, liver biopsy should be done for the early diagnosis and treatment.
出处
《临床肝胆病杂志》
CAS
2009年第3期175-177,共3页
Journal of Clinical Hepatology
