摘要
目的分析原发性胸腺淋巴瘤的临床和病理特征,探讨原发性胸腺淋巴瘤的合理治疗模式。方法收集并回顾性分析1990年～2007年间诊断为原发性胸腺淋巴瘤并接受治疗的27例患者的临床资料和治疗情况。结果初始治疗时有20例患者接受了综合治疗,其中8例患者为根治术加术后化疗,12例患者为肿物切除术后加全身化疗,两组5年生存率分别为23.0%和58.0%(P=0.006);其余有5例患者仅接受全身化疗,2例患者仅接受肿物切除手术。24例患者在初始治疗后取得完全缓解,1例患者部分缓解,2例患者疾病进展。随访38个月。全组患者5年总生存率和无病生存率分别是47.0%和23.0%;其中20例中高度恶性淋巴瘤患者5年总生存率和无病生存率分别是48.0%和27.0%。随访中有16例复发。结论原发性胸腺淋巴瘤的病理类型以中高度恶性淋巴瘤为主;根治性手术加术后化疗和放疗效果较好。
Objective To investigate ctinicopathologic features and optimal treatment of primary thymic lymphoma. Methods ClinicaI records of 27 primary thymic lymphoma patients treated from 1990 to 2007 were reviewed. Results Of the 27 patients, 8 received mastectory and chemotherapy, 12 received excision of the thymic lesion and chemotherapy, 5 received chemotherapy alone, and 2 received lesion excision alone. 24 achieved complete remission after scheduled treatment, 1 achieved partial remission, and 2 patients had progressive disease. With a follow-up of 10 years and median 38 months, the 5-year overall and disease-free survivaI rates of the 27 patients were 47% and 23 % respectively. Conclusion The main subtypes of primary thymic lymphoma are difuse large B-cell lymphoma and peripheral T-cell lymphoma. The optimal sequence is radical operation,followed by standard anthracycline-based regimens and radiotherapy.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2009年第5期1062-1064,共3页
Journal of Southern Medical University
关键词
胸腺肿瘤
淋巴瘤
thymic neoplasm
tymphoma
