摘要
目的观察缩泉丸对肾阳虚多尿模型大鼠肾脏加压素二型受体(AVPR-V2)表达的影响。方法用腺嘌呤250mg/kg灌服大鼠4周,造成肾阳虚多尿模型,分别给予缩泉丸、肾气丸和去氨加压素治疗4周,用免疫组化法检测缩泉丸对肾阳虚多尿模型大鼠肾脏AVPR-V2表达的影响。结果模型组肾小球、集合管、肾小管和肾小囊的内壁细胞上AVPR-V2的表达明显较正常组减弱,表现为棕黄色颗粒明显减少,颜色明显变浅,dDAVP组和缩泉丸高剂量组肾脏AVPR-V2表达比模型组明显升高。结论缩泉丸能够改善肾阳虚多尿模型大鼠肾脏AVPR-V2的表达。
Objective To observe the impacts of the formula of Suoquanwan（SQW） on expression of AVPR-V2 protein in the Kidney of rat polyuria model of Yang-deficiency. Method The model rats were induced by adenine （250mg/kg） for 4 weeks,then treated respectively with SQW,Shenqiwan and dDAVP. Expression of AVPR-V2 in kidney of Yang-deficiency model by immunohistochemistry method was investigated. Results In model rats,expression of AVPR-V2 in the plasma of the wall cells of glomerulus,collecting duct,renal tubule and Bowman capsule were deceased, dDAVP and SQW high dose can increased the expression of AVPR-V2 protein in the Kidney. Conclusion SQW can increase expression of AVPR-V2 protein in the Kidney of the rat polyuria model of Yang-deficiency.
出处
《中国老年保健医学》
2009年第3期12-14,共3页
Chinese Journal of Geriatric Care
基金
国家教育部博士点基金资助(20060572015)
