摘要
目的观察虫草活血胶囊治疗难治性肾病综合征的临床疗效。方法将100例难治性肾病综合征患者随机分为治疗组和对照组,各50例,2组均采用泼尼松、环磷酰胺等常规治疗,治疗组加服虫草活血胶囊,每次5粒,每日3次口服。2组均治疗6个月,随访6个月,观察治疗前后24h尿蛋白定量、血浆白蛋白及血脂指标变化。结果治疗组总有效率92%,对照组总有效率74%,2组比较差异有统计学意义(P<0.05);治疗组6个月复发率为12%,对照组6个月复发率为30%,2组比较差异有统计学意义(P<0.05);2组治疗前后血脂、血浆白蛋白、24h尿蛋白定量比较差异均有统计学意义(P<0.05),且2组治疗后比较差异均有统计学意义(P<0.05)。结论虫草活血胶囊不仅能提高机体免疫力,还能升高血浆白蛋白,降低24h尿蛋白定量,纠正脂质代谢紊乱状态,对降低近期复发率也有一定作用。
Objective To observe the effect of Qidanyishenjingtang pill on diabetic nephropathy. Methods 210 patients with diabetic nephropathy （DN） were randomly divided into two groups. Patients in control group （n = 100） were treated by routine therapy. Patients in treatment group （ n = 110） were treated by combination of Qida- nyishenjingtang pill and routine therapy. The changes of FPG,2 hPG, HblAc, 24 h urine protein, UAER, BUN, se- rum creatinine （Scr） , TC, TG, LDL - C, and HDL - C were observed before and after treatment. Results The to- tal effective rate in treatment group （ 82.73% ） was higher than that in control group（77.00% , P 〈0.05）. There were significant difference between two groups on FPG, 2hPG, HbAlc, 24 h urine protein, UAER, BUN, and Ser, after treatment （ P 〈 0.05 ）. There were significant difference between before and after treatment on TC, TG, HDL - L LDL - L in two groups （ P 〈 0.05 ）. Improvement of indexes in treatment group were superior to those in control group （ P 〈 0.05 ）. Conclusion Qidanyishenjingtang pill can decrease FPG in patient with DN, relief albuminuria and improve lipid metabolism.
出处
《河北中医》
2009年第5期658-659,662,共3页
Hebei Journal of Traditional Chinese Medicine
