摘要
目的：进一步验证实验所得出的升、降丹药的安全用药剂量。方法：对３１例外用红升丹及白降丹制剂的疮疡患者，在其用药前１天及用药１周后分别检测血汞浓度、血清谷丙转氨酶（ＡＬＴ）、尿素氮（ＢＵＮ）、肌酐（Ｃｒ）、过氧化脂质（ＬＰＯ）、超氧化物歧化酶（ＳＯＤ）。结果：用药后患者的血汞浓度较用药前虽有明显升高，但血清ＡＬＴ、ＢＵＮ、Ｃｒ、ＬＰＯ、ＳＯＤ在用药前后均无显著性差异，亦未出现汞中毒症状。结论：成人较长时间外用升、降丹制剂，如果每日外用九一丹、五五丹、白降丹的剂量分别不超过１．００ｇ、０．２０ｇ、０．０７ｇ对人体无明显的毒副作用。
Objective:To confirm the safety dosage of Sheng and Jiang Dan preparations obtained in previous laboratory study.Methods:The following values of 31 patients with skin diseases were detected one day before and one week after the application of Sheng and Jiang Dan preparations:serum glutamic pyruvic transaminase (ALT),urea nitrogen(BUN),creatinine(Cr),lipid peroxide(LPO),and superoxide dismutase (SOD).Results:Although the value of mercury is obviously increased after the application than before the application,no significant difference was observed in all the other values,ALT,BUN,Cr,LPO and SOD,and no symptoms or signs indicating hydrargyrism occurred.Conclusion:Relatively long time application of Sheng and Jiang Dan preparations on adults will not cause any toxic or side effects if the daily dosage of the external application of Jiu Yi Dan,Wu Wu Dan and Bai Jiang Dan does not surpass 1.00g,0.20g,and 0.07g respectively.
出处
《南京中医药大学学报》
CAS
CSCD
1998年第4期215-216,共2页
Journal of Nanjing University of Traditional Chinese Medicine
基金
江苏省科委资助
关键词
红升丹
白降丹
毒性
汞
Hong Sheng Dan,Bai Jiang dan,toxicity,mercury
