摘要
目的探讨血清尿酸(BUA)升高与过敏性紫癜肾炎(HSPN)的相互关系。方法对50例过敏性紫癜(HSP)患儿不同病程的BUA、血尿素氮(BUN)、血肌酐(SCr)、尿常规、尿β2-微球蛋白(Uβ2-MG)、尿微量白蛋白(UMA)、N-乙酰-β-氨基葡萄苷酶(NAG)进行测定,并对BUA升高的部分患儿实行干预治疗。平均随访8.5个月。结果(1)HSP出现BUA升高31例(62%);(2)HSP继发HSPN 23例(46%);(3)继发HSPN中BUA升高18例(78.3%),而仅表现为HSP的患儿中BUA升高13例(48.1%),2组差异有统计学意义(P<0.01);(4)与BUA不升高的5例HSPN相比,18例BUA升高者其病情程度无明显加重(P>0.05);(5)对BUA升高者中10例HSPN进行干预治疗,与无干预的另8例HSPN相比,病程明显缩短(P<0.05)。结论HSP患儿BUA升高与HSPN发病率及病程相关,但与肾损害程度无明显相关性,干预治疗高尿酸血症可缩短HSPN病程。
Objective To explore the relationship between serum uric acid and Seh？ nlein-Henoch purpura nephritis （SHPN）. Methods BUA, BUN SCr, uric routine, Uβ2-MG, LIMA, NAG were measured in 50 children patients with Sch？ nlein-Hencch purpura （SHP）. A part of the children whose BUA was high were treated. The mean tirne of follow-up was 8. S months. Results （1） BUA rose in 31cases of SHP（62% ） ,（2） SHP developed to SHPN in 23 eases （46 % ） ,（3） BUA rose in 18 cases of secondary SHPN （78.3%）, and BUA rose in 13 patients with SHP hut without SHPN （48.1% ）. There was a significant difference between the two groups, P 〈 0.01. （4） The condition in 18 eases of BUA rising was not significantly serious compared with the normal group of BUA in all the HSPN, P 〉0.05. （5） The course of disease was significantly shorter in the treated group （10 cases） than in the untreated group （8 cases, P 〈 0.05）. Conclusions The incidence and severity of HSPN are related to the rising of BUA. The injury of kidney has no relationship with the rising of BUA. Treating the high BUA could shorten the course of HSPN.
出处
《中国校医》
2009年第3期266-267,共2页
Chinese Journal of School Doctor
关键词
尿酸
血清学检验
紫癜
过敏性
肾炎
儿童
Uric Acid
Serologic Tests
Schonlein-Henoeh Purpura(SHP),Nephritis
Child
