摘要
随着配型技术及新型免疫抑制剂的临床应用,器官或组织移植术后早期急性免疫排斥反应发生率明显下降,慢性移植物失功则成为导致远期移植失败的主要原因之一。研究表明角膜移植术后和全身器官移植术后同样存在角膜植片慢性失功的过程,且角膜植片慢性失功已经成为再次角膜移植的主要原因之一。因此,重视角膜植片慢性失功对其临床防治及延长角膜植片的存活率有着重要的意义。
With the clinical application of new technology and immunosuppressive drugs, the early acute graft rejection have been significantly decreased. However, chronic graft failure in long-term transplantation has become one of the most important reasons. As the same as body solid organ transplantation, chronic corneal allograft dysfunction is present after penetrating keratoplasty and has been one of the main reasons of causing repeat keratoplasty. Therefore, studying the mechanism of chronic allograft dysfunction will be of the most important significance in clinical prevention and treatment for chronic graft corneal transplant failure, especially in prolongation of corneal grafts survival rate.
出处
《眼科》
CAS
2009年第3期145-147,共3页
Ophthalmology in China
关键词
角膜植片慢性失功
角膜移植术
角膜内皮细胞
chronic corneal allograft dysfunction
corneal transplantation
corneal endothelial cell
